中药治疗寒湿凝滞型盆腔炎性疾病伴炎性包块及对T细胞、血清C-反应蛋白的影响

目的:观察中药干预寒湿凝滞型盆腔炎性疾病伴炎性包块的临床疗效,并考察其对患者T细胞、血清中C-反应蛋白的影响。方法:将寒湿凝滞型盆腔炎性疾病患者60例随机分为2组,治疗组40例予自拟消炎汤,每日1剂,连服14天。对照组20例口服莫西沙星,一次400 mg/片,每日1次,连服7天。结果:治疗组总有效率为85.00%(95%CI=73.93%~96.07%);对照组为70.00%(95%CI=49.92%~90.08%);两组综合疗效比较(u=0.793 8,P=0.427 3),差异未达到显著性意义;与对照组比较,治疗组能缩小包块(t'=-5.442 4,P0.01),升高血中CD+4含量,降低CD+8、CRP参数(P0.01)。结论:自拟消炎汤中药干预寒湿凝滞型盆腔炎性疾病伴炎性包块的临床疗效优于莫西沙星的临床证据尚不充分,其收益为OR=0.41(95%CI=0.11~1.50),NNT=7(95%CI=2.74~22.12);但可缩小患者的炎性包块;提高患者血中CD+4,降低CD+8、CRP参数。

Clinical Observation of Traditional Chinese Medicine on Pelvic Inflammatory Disease with Inflammatory Mass due to cold-damp Stagnation and Effect on Serum T cell,C-reactive Protein

Objective： To observe the clinical effectiveness of treating the cold-damp stagnation type of pelvic inflammatory disease with inflammatory mass by traditional Chinese medicine and its effect on T cells, C- reactive protein in the serum of the patients. Methods ： 60 cases with pelvic inflammatory disease due to cold-damp stagna- tion were randomly divided into two groups. 40 cases of treatment group were treated with Xiaoyan decoction for 14 days. 20 cases of control group were treated with oral moxifloxacin for 7 days. The inflammatory mass of the two groups were both narrowed, and the serum T lymphocyte subsets and C-reactive protein level changed before and after treatment. Results： After treatment, the total effective ＇rate of the treatment group was 85.00% （95% CI = 73.93 % -96.07% ）, that of the control group was 70. 00% （95 % CI = 49.92% - 90.08% ）. The total effective rate between the two groups had no significant difference （ u = 0. 793 8,P = 0. 427 3）. Compared with the control group, the inflammatory mass volume of the treatment group decreased （t＇ = -5. 442 4, P 〈 0.01 ）. In addition, the treatment group could significantly increase the content of serum CD4＋ , and decrease CDs＋ , CRP content （P 〈 0.05 ）. Conclusion ： Compared with moxifloxacin, the clinical effectiveness of Xiaoyan decoction on pelvic inflam- matory disease with inflammatory mass due to cold-damp stagnation has not gained enough evidence, OR = 0.41 （95%CI=0.11 -1.50）, NNT=7 （95%CI=2.74-22.12）.