| 宣肺汤对小鼠B16黑素瘤细胞代谢的影响 |
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| 引用本文： | 李如辉,朱乔青,包素珍,王静波.宣肺汤对小鼠B16黑素瘤细胞代谢的影响[J].中国中医药科技,2010,17(2):102-103. |
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| 作者姓名： | 李如辉 朱乔青 包素珍 王静波 |
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| 作者单位： | 浙江中医药大学,杭州,310053 |
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| 基金项目： | 浙江中医药管理局资助项目No.2006C007 |
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| 摘 要： | 目的：观察宣肺汤对：B16黑素瘤细胞的作用，探讨其关白作用的机理及安全性。方法：测定宣肺汤对体外培养的B16黑素瘤细胞细胞活力、酪氨酸酶活性及细胞内黑素含量的影响，并与熊果苷作对照比较。结果：25、50、100μg／ml宣肺汤对黑素瘤细胞的细胞增殖、酪氨酸酶活性及黑素生成均有较强的抑制作用，并呈剂量依赖性，且优于同浓度熊果苷，差异均有统计学意义（P〈0．05或P〈0．01）。结论：宣肺汤有较强的抑制黑素瘤细胞增殖、酪氨酸酶活性和黑素生成的作用，同时对黑素瘤细胞的细胞毒性较低，是较为安全有效的美白药物。
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| 关 键 词： | 黑色素瘤／中医药疗法 @宣肺汤／治疗应用 体外研究 小鼠 |
EFFECT OF XUANFEI DECOCTION ON CELLULAR METABOLISM OF B16 MELAROMA OF MICE |
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| LI Ru-hui,ZHU Qiao-qing,BAO Su-zhen,et al.EFFECT OF XUANFEI DECOCTION ON CELLULAR METABOLISM OF B16 MELAROMA OF MICE[J].Chinese Journal of Traditional Medical Science and Technology,2010,17(2):102-103. |
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| Authors: | LI Ru-hui ZHU Qiao-qing BAO Su-zhen |
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| Institution: | LI Ru-hui,ZHU Qiao-qing,BAO Su-zhen,et al(Zhejiang University of Traditional Chinese Medicine,Hangzhou310053) |
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| Abstract: | Objective:To observe the effect of xuanfei decoction on B16 melaroma cells and discuss the mechanism of whitening function and safety.Methods:To determine the effects of xuanfei decoction on cytoactive and tyrosinase of B16 melaroma cells and melanin content,arbutin was taken as control.Results:Xuanfei decoction could inhibit the cellular proliferation,activity of tyrosinase and melanin formation of B16 melaroma cells,the effects were better than those of arbutin group,there was obviously difference between... |
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| Keywords: | Xuanfei decoction is a safe effective medicine of whitening inhibiting cellular proliferation activity of tyrosinase and melanin formation of B16 melaroma cells was its part of mechanism |
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