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长蛇灸对强直性脊柱炎患者血清基质金属蛋白酶3及基质金属蛋白酶组织抑制因子1的影响
引用本文:刘晓安,左祖俊,揭平,何鹏,邹三明,罗望翠,田荣华,刘自刚,刘波,刘锋.长蛇灸对强直性脊柱炎患者血清基质金属蛋白酶3及基质金属蛋白酶组织抑制因子1的影响[J].中国中医药科技,2011,18(3):183-184,176.
作者姓名:刘晓安  左祖俊  揭平  何鹏  邹三明  罗望翠  田荣华  刘自刚  刘波  刘锋
作者单位:华中科技大学同济医学院附属孝感医院·孝感市中心医院·孝感,432100
基金项目:湖北省卫生厅立项科研课题No.2008Z-B04
摘    要:目的:观察长蛇灸对早中期强直性脊柱炎患者血清基质金属蛋白酶3(MMP-3)和基质金属蛋白酶组织抑制因子1(TIMP-1)的影响。方法:将60例早中期强直性脊柱炎患者随机分为两组,治疗组30例,采用长蛇灸进行治疗;对照组30例,口服柳氮磺胺吡啶治疗。观察两组患者治疗前后血清MMP-3和TIMP-1水平的变化。结果:两组患者治疗后血清MMP-3明显下降(P〈0·01~0·05),但治疗组下降更显著,与对照组比较,有极显著性差异(P〈0·01);两组患者治疗后血清TIMP-1明显升高(P〈0·01),但治疗组升高更显著,与对照组比较,有显著性差异(P〈0·05)。结论:长蛇灸治疗早中期强直性脊柱炎,可减少致炎因子的释放,调节异常的基质降解和减少血管形成等炎症的病理因素,缓解AS炎症、减少软骨和骨质破坏。

关 键 词:脊柱炎  强直性/针灸疗法  基质金属蛋白酶3/针灸效应  基质金属蛋白酶组织抑制因子/针灸效应  长蛇灸  人类

Effects of Hydra Moxibustion on Serum Matrix Metalloproteinase - 3 and Tissue Inhibitor of Matrix Metalloprcteinase - 1in Ankylosing Spondylitis Patients
LIU Xiaoan,ZUO Zujun,JIE Ping,et al.Effects of Hydra Moxibustion on Serum Matrix Metalloproteinase - 3 and Tissue Inhibitor of Matrix Metalloprcteinase - 1in Ankylosing Spondylitis Patients[J].Chinese Journal of Traditional Medical Science and Technology,2011,18(3):183-184,176.
Authors:LIU Xiaoan  ZUO Zujun  JIE Ping  
Institution:LIU Xiaoan,ZUO Zujun,JIE Ping,et al(Xiaogan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Xiaogan 432100)
Abstract:Objective:To observe the effects of Hydra moxibustion on serum matrix metalloproteinase-3(MMP-3) and tissue inhibitor of matrix metalloproteinase-1(TIMP-1) of patients with ankylosing spondylitis at early and mild period.Methods:60 Cases with ankylosing spondylitis at early and mild period were randomly divided into two groups,the observed group was given Hydra moxibustion to treat,the control group was given sulfasalazine to oral,the changes of serum MMP-3 and TIMP-1 in the two groups wre determined before...
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