参芪扶正注射液预防放射性心脏损伤临床观察

目的:观察参芪扶正注射液预防放射性心脏损伤临床疗效及对心肌肌钙蛋白T(cTnT)的影响.方法:将胸部恶性肿瘤放射治疗患者随机分为治疗组和对照组,治疗组予以对症支持治疗配合参芪扶正注射液静脉滴注,对照组仅予对症支持治疗.结果:治疗组比对照组心律失常情况明显好转,差异有显著性意义(P＜0.05);在DT=60～70GY时,治疗纽和对照组的cTnT变化情况比较有显著性差异(P＜0.05).结论:参芪扶正注射液可预防放射性心脏损伤,并可抑制放射治疗后心肌肌钙蛋白,对放射性心脏损伤有一定治疗作用.

Clinical effect of Shenqi Fuzheng injection in preventing radiation-induced myocardial damage

Objective: To observe the clinical effect of Shenqi Fuzheng injection in preventing radiation-induced myocardial damage and its influence on serum cardiac troponin T(cTnT) level.Methods: Patients with malignant thoracic tumor who had received radiotherapy were randomly divided into treatment group and control group.The treatment group received symptomatic/supportive treatment as well as Shenqi Fuzheng injection(i.v.drip),while the control group received symptomatic/supportive treatment alone.Results: The treatment group showed a significantly better improvement in symptoms of arrhythmia than the control group(P<0.05).When the total dose was 60-70 Gy,there was a significant difference in cTnT level change between the two groups(P<0.05).Conclusion: Shenqi Fuzheng injection can prevent radiation-induced myocardial damage and inhibit increase in cTnT level after radiotherapy and has some therapeutic effect on radiation-induced myocardial damage.