| 通脉养心丸干预冠心病稳定性心绞痛气阴两虚证的临床生化基础研究 |
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| 引用本文： | 徐一兰,高杉,邓兵,毛美娇,杜廷海,李彬,杨宝平,于研,张虹,张世姝,毛静远,王贤良,徐强,张蕾,宋光明,田莉,王丽,闫丹丹,李琳,高树明,潘晔,蔡雪朦,王朔,李晓枫,艾乐,胡镜清,边育红,于春泉. 通脉养心丸干预冠心病稳定性心绞痛气阴两虚证的临床生化基础研究[J]. 天津中医药, 2019, 36(1): 18-22 |
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| 作者姓名： | 徐一兰 高杉 邓兵 毛美娇 杜廷海 李彬 杨宝平 于研 张虹 张世姝 毛静远 王贤良 徐强 张蕾 宋光明 田莉 王丽 闫丹丹 李琳 高树明 潘晔 蔡雪朦 王朔 李晓枫 艾乐 胡镜清 边育红 于春泉 |
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| 作者单位： | 天津中医药大学;上海中医药大学附属龙华医院;河南中医药大学第一附属医院;甘肃省中医院;天津市南开医院;天津中医药大学第一附属医院;天津中医药大学第二附属医院;天津市武清区中医医院;天津市第二人民医院;天津中新药业集团股份有限公司乐仁堂制药厂;中国中医科学院中医基础理论研究所 |
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| 基金项目： | 国家重点基础研究发展计划（973计划）项目（2014CB542902）。 |
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| 摘 要： | [目的]通过多中心、精细化的临床研究,旨在对比通脉养心丸干预的冠心病稳定性心绞痛气阴两虚证患者和健康人的临床生化指标,探讨其临床生化基础。[方法]从全国7家临床研究中心共入组受试者82例,其中脱失3例,最终纳入冠心病气阴两虚证患者39例,在西医常规治疗的基础上加服中药通脉养心丸治疗,健康人40例不予干预。分别检测内皮细胞损伤、脂质代谢、黏附分子、炎症介质、金属蛋白酶、同型半胱氨酸和凝血功能共7类28项指标,冠心病患者分别检测0、8、12周水平,健康人检测第0周水平。[结果]冠心病气阴两虚证与载脂蛋白B、低密度脂蛋白、血管紧张素Ⅱ相关性较大,经过通脉养心丸的治疗,血管紧张素Ⅰ、血浆内皮素升高,可溶性CD40配体水平下降(P0.05)。整体炎症因子水平有下降趋势。[结论]通脉养心丸调控冠心病稳定性心绞痛气阴两虚证的生化基础与内皮损伤、脂质代谢、炎症因子有关,可为进一步研究提供参考依据。
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| 关 键 词： | 冠心病稳定性心绞痛 气阴两虚证 临床生化 多中心 精细化 |
| 收稿时间： | 2018-10-15 |
Clinical and biochemical basic research of the qi and yin deficiency syndrome of coronary heart disease stable angina |
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| XU Yilan,GAO Shan,DENG Bing,MAO Meijiao,DU Tinghai,LI Bin,YANG Baoping,YU Yan,ZHANG Hong,ZHANG Shishu,MAO Jingyuan,WANG Xianliang,XU Qiang,ZHANG Lei,SONG Guangming,TIAN Li,WANG Li,YAN Dandan,LI Lin,GAO Shuming,PAN Ye,CAI Xuemeng,WANG Shuo,LI Xiaofeng,AI Le,HU Jingqing,BIAN Yuhong and YU Chunquan. Clinical and biochemical basic research of the qi and yin deficiency syndrome of coronary heart disease stable angina[J]. Tianjin Journal of Traditional Chin Medicine, 2019, 36(1): 18-22 |
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| Authors: | XU Yilan GAO Shan DENG Bing MAO Meijiao DU Tinghai LI Bin YANG Baoping YU Yan ZHANG Hong ZHANG Shishu MAO Jingyuan WANG Xianliang XU Qiang ZHANG Lei SONG Guangming TIAN Li WANG Li YAN Dandan LI Lin GAO Shuming PAN Ye CAI Xuemeng WANG Shuo LI Xiaofeng AI Le HU Jingqing BIAN Yuhong YU Chunquan |
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| Affiliation: | Tianjin University of Traditional Chinese Medicine, Tianjin 301617,Tianjin University of Traditional Chinese Medicine, Tianjin 301617,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 136300, China,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 136300, China,Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730699, China,Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730699, China,Tianjin Nankai Hospital, Tianjin 300100, China,Tianjin Nankai Hospital, Tianjin 300100, China,The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China,Tianjin Wuqing Hospital of Traditional Chinese Medicine, Tianjin 301700, China,Tianjin Wuqing Hospital of Traditional Chinese Medicine, Tianjin 301700, China,Tianjin Wuqing Hospital of Traditional Chinese Medicine, Tianjin 301700, China,Tianjin Second People Hospital, Tianjin 300192, China,Tianjin University of Traditional Chinese Medicine, Tianjin 301617,Tianjin University of Traditional Chinese Medicine, Tianjin 301617,Tianjin University of Traditional Chinese Medicine, Tianjin 301617,Tianjin University of Traditional Chinese Medicine, Tianjin 301617,Tianjin University of Traditional Chinese Medicine, Tianjin 301617,Tianjin University of Traditional Chinese Medicine, Tianjin 301617,Tianjin University of Traditional Chinese Medicine, Tianjin 301617,Tianjin Zhongxin Pharmaceutical Group Limited by Share Ltd. Lerentang Pharmaceutical Factory, Tianjin 300112, China,Institue of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medicine Science, Beijing 100070, China,Tianjin University of Traditional Chinese Medicine, Tianjin 301617 and Tianjin University of Traditional Chinese Medicine, Tianjin 301617 |
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| Abstract: | |
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| Keywords: | coronary heart disease stable angina pectoris qi and yin deficiency syndrome clinical biochemistry multi-centers finesse |
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