丹参注射液穴位注射在2型糖尿病强化治疗中的作用

目的]在2型糖尿病患者胰岛素强化治疗的基础上予以针灸干预治疗(丹参注射液于足三里、三阴交穴位注射),明确其在临床糖尿病治疗中的作用和地位。方法]选择2型糖尿病患者共60例,分为治疗组和对照组,比较治疗前后生化指标、胰岛素和C-肽分泌水平的变化,评估胰岛β细胞功能和胰岛素抵抗程度,并进行治疗经济学评价。结果]治疗组低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、餐后2 h血糖(P2hPG)、游离脂肪酸(FFA)、C反应蛋白水平(CRP)较对照组明显下降(P<0.05),静脉葡萄糖耐量试验显示治疗组各时点血糖水平下降显著(P<0.05),血清胰岛素的第一时相分泌缺陷能较好修正(P<0.05),HOMA-IR(C-P)、HOMA-islet(C-P)改善明显(P<0.05)。两组所需胰岛素用量(日用量和总用量)、住院治疗总费用及日费用比较差异无统计学意义(P>0.05),但治疗组血糖达标时间较对照组明显缩短(P<0.05)。结论]在2型糖尿病患者进行胰岛素强化治疗的基础上辅以丹参注射液穴位注射不能获得直接的短期经济效益,然而能更加有效纠正患者糖脂代谢紊乱状况,改善第一时相胰岛素分泌及胰岛β细胞功能、恢复机体对胰岛素的敏感性方面具有积极作用。

Clinical effect of point injection with Danshen injection in diagnosed patients with type 2 diabetes mellitus in intensive insulin therapy

Objective] To study the clinical effect of point injection with Danshen injection (Zu san li point and San yin jiao point) in newly diagnosed patients with type 2 diabetes mellitus on the basis of intensive insulin therapy. Methods] Sixty newly diagnosed patients with type 2 diabetes mellitus were chosen and randomly divided into treatment group and control group. The biochemical indicators, insulin and C-p levels were compared and the beta cell function, insulin resistance level and treatment economics were evaluated. Results] The LDL-C, FBG, P2hPG, FFA, CRP levels in treatment group were lower than that in control group (P<0.05). The intravenous glucose tolerance test showed that the blood glucose in every time point was decreased in treatment group (P<0.05). The improvement of HOMA-IR(C-P) and HOMA-islet(C-P) were also more obvious than control group(P<0.05). There was no significant difference in necessary insulin amount, hospital expenses(daily and total) in two groups(P>0.05), but patients in treatment group paid shorter time to reach the standard goal than control group(P<0.05). Conclusion] Even no short-term economic benefit acquired by point injecting Danshen injection on the basis of intensive insulin therapy, but it could actively correct glucolipid metabolism disorders, improve the insulin secretion in the first phase and the function of beta cell inlet and recover body sensitivity to insulin.