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慢性阻塞性肺疾病痰瘀阻肺证大鼠模型的建立
引用本文:李泽庚,王传博,彭波,童佳兵,杨程,张四春.慢性阻塞性肺疾病痰瘀阻肺证大鼠模型的建立[J].天津中医药,2010,27(1):43-45.
作者姓名:李泽庚  王传博  彭波  童佳兵  杨程  张四春
作者单位:安徽中医学院第一附属医院,合肥,230031
基金项目:国家重点基础研究发展计划(973计划)项目,国家自然基金项目 
摘    要:目的】采用病证结合的造模方法建立慢性阻塞性肺疾病(以下简称慢阻肺)痰瘀阻肺证大鼠模型。【方法】利用强迫游泳、烟熏、低氧环境耗伤肺气,使其肺气虚,引起痰饮瘀血内停,建立慢阻肺痰瘀阻肺证大鼠模型。4周后测大鼠肺功能、肺动脉压、血流变及心肺病理学观察。结果】模型大鼠的症状、肺功能、肺动脉压、血流变及心肺病理学观察符合慢阻肺痰瘀阻肺证的表现。结论】实验采用复合因素造模方法复制的慢阻肺痰瘀阻肺证模型符合中医学和现代医学原理,具有时间短、易复制、可操作性强的特点,亦符合临床的实际情况。

关 键 词:慢性阻塞性肺疾病  痰瘀阻肺证  大鼠模型
收稿时间:2009/10/12 0:00:00

Establishment of rat model of chronic obstructive pulmonary disease with stagnated phlegm obstructing lung
LI Ze-geng,WANG Chuan-bo,PENG Bo.Establishment of rat model of chronic obstructive pulmonary disease with stagnated phlegm obstructing lung[J].Tianjin Journal of Traditional Chin Medicine,2010,27(1):43-45.
Authors:LI Ze-geng  WANG Chuan-bo  PENG Bo
Institution:LI Ze-geng,WANG Chuan-bo,PENG Bo,et al (The First Affiliated Hospital of Anhui College of TCM,Hefei 230031,China)
Abstract:Objective] To establish the rat model of chronic obstructive pulmonary disease (COPD) with stagnated phlegm obstructing lung by combining the disease and symptoms.Methods] The COPD with stagnated phlegm obstructing lung was established in rats with compelled swimming,exploding in the circumstances of smoke and hypoxia for 4 weeks.The pulmonary function,pulmonary arterial pressure,blood rheology and the pathological changes of the rats' lung and heart were observed.Results] The symptoms,pulmonary function...
Keywords:COPD  stagnated phlegm obstructing lung  the rat model  
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