首页 | 本学科首页   官方微博 | 高级检索  
检索        

加减补肺汤对COPD肺气虚证模型大鼠支气管肺泡灌洗液TNF-α、IL-8的影响
引用本文:张葵,刘良丽,欧江琴,谌洪俊,刘华蓉.加减补肺汤对COPD肺气虚证模型大鼠支气管肺泡灌洗液TNF-α、IL-8的影响[J].天津中医药,2008,25(6):491-493.
作者姓名:张葵  刘良丽  欧江琴  谌洪俊  刘华蓉
作者单位:贵阳中医学院第一附属医院呼吸科,贵阳,550001
摘    要:目的]研究加减补肺汤对慢性阻塞性肺疾病(COPD)肺气虚证模型对支气管肺泡灌洗液肿瘤坏死因子-α(TNF-α)、白介素细胞-8(IL-8)表达及大鼠气道病理改变的影响,探讨加减补肺汤治疗COPD肺气虚证的机制.方法]用烟熏并复合木瓜蛋白酶雾化吸入法复制COPD"肺气虚证"大鼠模型,将100只雌雄各半大鼠随机分为5组:正常组、模型组、补高组、补低组、桂龙组.治疗后.光镜观察大鼠支气管、肺组织病理改变,放免法检测大鼠支气管肺泡灌洗液TNF-α、IL-8水平.结果]与正常对照组比较,造模组支气管管腔及周围炎性细胞浸润,纤毛粘连、倒伏、脱落,肺泡扩大融合,数量减少;支气管肺泡灌洗液中TNF-α、IL-8高表达,各治疗组以上改变均明显减轻.以补高组最为显著(P<0.01).结论]加减补肺汤具有缓解气道炎症的作用.对COPD肺气虚证疗效确切.

关 键 词:加减补肺汤  慢性阻塞性肺疾病  肺气虚证  TNF-α:IL-8
收稿时间:4/7/2008 12:00:00 AM

Effect of Jiajianbufei decoction on TNF-a and IL-8 of bronchoalveolar lavage fluid in COPD rats with deficiency of Lung-qi
ZHANG Kui,LIU Liang-li,OU Jiang-qin.Effect of Jiajianbufei decoction on TNF-a and IL-8 of bronchoalveolar lavage fluid in COPD rats with deficiency of Lung-qi[J].Tianjin Journal of Traditional Chin Medicine,2008,25(6):491-493.
Authors:ZHANG Kui  LIU Liang-li  OU Jiang-qin
Institution:ZHANG Kui,LIU Liang-li,OU Jiang-qin,et al (The First Hospital Affiliated to Guiyang College of TCM,Guiyang 550001,China)
Abstract:Objective] To study the effect of Jiajianbufei(modified decoction for tonifying the lung) decoction on TNF-a and IL-8 of bron- choalveolar lavage fluid in COPD rats with deficiency of lung-qi and to explore the mechanism of it in treating deficiency of lung-qi of COPD rats. Methods] Deficiency of lung-qi of COPD in rats was established by using smudging and caroid aerosol rebreathing method. One hundred rats were randomly divided into five groups: normal group, model group, high dosage of Jiajianbufei dec...
Keywords:Jiajianbufei decoction  chronic obstructive pulmonary diseases(COPD)  deficiency of lung-qi  TNF-a  IL-8  
本文献已被 CNKI 维普 万方数据 等数据库收录!
点击此处可从《天津中医药》浏览原始摘要信息
点击此处可从《天津中医药》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号