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金黄膏外敷治疗糖尿病溃疡的实验研究
引用本文:王军,杨瑞,袁向科,徐阳,严豪杰,付赢.金黄膏外敷治疗糖尿病溃疡的实验研究[J].天津中医药,2010,27(4):325-327.
作者姓名:王军  杨瑞  袁向科  徐阳  严豪杰  付赢
作者单位:天津中医药大学第一附属医院外科,天津,300193
基金项目:天津市高等学校科技发展基金计划项目 
摘    要:目的]从动物实验探讨金黄膏对糖尿病溃疡的治疗作用机制。方法]SD大鼠,诱发糖尿病皮肤溃疡模型,随机分为A金黄膏组、B普通胰岛素组、C凡士林组,分时段观察肉芽组织中成纤维细胞数、血管内皮细胞生长因子(VEGF)、CD34、新生毛细血管数。结果]A组在纤维细胞数、新生毛细血管数及VEGF、CD34等指标与B组、C组比较均有显著性差异。结论]金黄膏具有明显的促进糖尿病溃疡愈合作用,可能是通过促进成纤维细胞和新生毛细血管的增殖、加快肉芽组织的形成来体现。

关 键 词:2型糖尿病  皮肤溃疡  中医外治  金黄膏
收稿时间:6/6/2010 12:00:00 AM

Experiment Study on External Application of Golden-yellow Ointment in Treating Diabetic Ulcers
WANG Jun,YANG Rui,YUAN Xiang-ke.Experiment Study on External Application of Golden-yellow Ointment in Treating Diabetic Ulcers[J].Tianjin Journal of Traditional Chin Medicine,2010,27(4):325-327.
Authors:WANG Jun  YANG Rui  YUAN Xiang-ke
Institution:The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China;The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China;The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China;The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China;The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China;The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China
Abstract:Objective] To explore the effect mechanism of Golden-yellow Ointment in treating diabetic ulcers with animal experiments. Methods] The SD rats with diabetic skin ulcers were randomly divided into Golden-yellow Ointment(Group A),ordinary insulin(Group B),Vaseline group(Group C).Granulation tissue fibroblasts,VEGF,CD34,the number of new capillaries were observed. Results] The fiber cells,the number of new blood capillaries and VEGF,CD34 and other indicators in Group A compared with Group B,C were significantly different. Conclusion] The Golden-yellow Ointment may obviously enhance diabetic ulcer healing,the effect mechanism was possibly by promoting fibroblast proliferation and new blood capillaries,speeding up the formation of granulation tissue.
Keywords:Type 2 diabetes  Skin ulcer  external treatment of Traditional Chinese Medicine  Golden-yellow Ointment
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