| 生脉注射液对心力衰竭患者地戈辛血药浓度和药动学参数影响的临床研究 |
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| 引用本文： | 毛静远,王恒和,王强,常延平,张其梅,郑颖,吴慧轩,张宇,李红,张运.生脉注射液对心力衰竭患者地戈辛血药浓度和药动学参数影响的临床研究[J].天津中医药,2003,20(2):14-16. |
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| 作者姓名： | 毛静远 王恒和 王强 常延平 张其梅 郑颖 吴慧轩 张宇 李红 张运 |
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| 作者单位： | 1. 天津中医学院第一附属医院,天津,300193
2. 天津中医学院,天津,300193 |
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| 基金项目： | 天津市教委科技发展基金资助项目(20010909) |
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| 摘 要： | 目的]探讨生脉注射液对心力衰竭患者地戈辛血药浓度和药动学参数的影响。方法]选择符合标准的充血性心衰患者40例 ,随机分为地戈辛组和地戈辛 +生脉注射液20、40、60mL3个剂量组 ,每组10例 ,采用放免法(RIA)分别测定4组患者不同时间地戈辛血药浓度 ,以3P97药动学软件拟合地戈辛药动学参数。结果]生脉注射液小剂量 (20mL)组对心衰患者地戈辛血药浓度和消除半衰期 (T1/2)、表观分布容积 (Vd)、血浆清除率 (CL)等药动学参数有显著影响 (P<0.05) ,而中剂量(40mL)和大剂量 (60mL)组无明显影响(P>0.05)。结论]提示生脉注射液在小剂量应用时具有降低充血性心衰患者地戈辛血药浓度、缩短消除半衰期的作用。
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| 关 键 词： | 生脉注射液 地戈辛 血药浓度 药代动力学 充血性心力衰竭 |
| 文章编号： | 1672-1519(2003)02-0014-03 |
| 收稿时间： | 2002/10/14 0:00:00 |
| 修稿时间： | 2002年10月14 |
Clinical effect of Shengmai Injection on blood digoxin concentration and pharmacokinetics in patients with heart failure |
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| Mao Jing-yuan,Wang Heng-he,Wang Qiang.Clinical effect of Shengmai Injection on blood digoxin concentration and pharmacokinetics in patients with heart failure[J].Tianjin Journal of Traditional Chin Medicine,2003,20(2):14-16. |
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| Authors: | Mao Jing-yuan Wang Heng-he Wang Qiang |
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| Institution: | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract: | Objective] To study the clinical effect of Shengmai Injection on blood digoxin concentration and pharmacoki-netics in patients with heart failure. Method] Forty cases with congestive heart failure were randomly divided into 4 groups:group 1(Digoxin),group 2,3,4(Digoxin and Shenmai Injection with 20mL,40mL,60mL respectively).Each group had 10cases.The blood concentration of Digoxin in all groups was detected with radioimmunoassay(RIA)and the pharmacokinetics parameter,were calculated with 3P97 pharmacokinetics software. Result] There was an obvious differ-ence between group1and group 2 in pharmacokinetics parameters(P<0.05),such as the blood digoxin concentration,T(1/2),Vd,CL,and so on.But there was no difference between group1and group 3,group1and group 4 (P>0.05). Conclusion] Shengmai Injection with low dosage can decrease the blood digoxin concentration and shorten T(1/2)in the patients with congestive heart failure. |
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| Keywords: | Shengmai Injection Digoxin blood concentration pharmacokinetics congestive heart failure |
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