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强骨丹对去卵巢大鼠骨质疏松症防治作用的实验研究
引用本文:王玲,哈孝贤,于顺禄,李彦,王志华,玄明实.强骨丹对去卵巢大鼠骨质疏松症防治作用的实验研究[J].天津中医药,2004,21(5):398-401.
作者姓名:王玲  哈孝贤  于顺禄  李彦  王志华  玄明实
作者单位:1. 天津中医学院,天津,300193
2. 天津市骨科医院骨科研究所,天津,300211
基金项目:天津市自然科学基金项目 (990539)
摘    要:【目的】探讨中药强骨丹对绝经后骨质疏松症的防治作用。【方法】运用切除大鼠卵巢方法建立去卵巢骨质疏松症模型,随机分为模型组、强骨丹高低剂量组、西药组,同时设假手术对照组。采用双能X线骨密度测定法、放射免疫分析法和ELISA法等检测各组实验鼠骨密度(BMD)、骨矿含量(BMC)、血清雌二醇(E2)、骨钙素(BGP)、抗酒石酸酸性磷酸酶5b(TRACP5b)以及尿脱氧吡啶啉(Dpol)。【结果】强骨丹可明显升高BMD、BMC,提高血清E2水平,降低TRACP5b和Dpd水平,并降低BGP含量。【结论】强骨丹通过调节机体相关内分泌功能,抑制骨吸收,降低骨的转换率,减少骨丢失,增加骨密度对绝经后骨质疏松症有防治作用。

关 键 词:防治作用  绝经后骨质疏松症  大鼠  骨密度  BMD  实验研究  尿脱氧吡啶啉
文章编号:1672-1519(2004)05-0398-04
收稿时间:4/4/2004 12:00:00 AM
修稿时间:2004年4月4日

Preventive and Therapeutic Effect of Qianggu Dan on Osteoporosis in Ovariectomized Rats
WANG Ling,HA Xiao-xian,YU Zhun-lu.Preventive and Therapeutic Effect of Qianggu Dan on Osteoporosis in Ovariectomized Rats[J].Tianjin Journal of Traditional Chin Medicine,2004,21(5):398-401.
Authors:WANG Ling  HA Xiao-xian  YU Zhun-lu
Institution:Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Abstract:Objective] To investigate the preventive and therapeutic effect of Qianggu Dan(Strengthening bone pill)on the postmenopausal osteoporosis. Methods] The disease was induced by ovariectomy.in rats.They were randomly divided into5groups:model group,Qianggu Dan high dosage group and low dosage group,western medicine group and the sham op-eration group.Bone mineral density(BMD),bone mineral content(BMC),serum estradiol(E2),bone calcium plain(BGP),tartaric resting acid phosphorus5b(TRACP5b) and urine deoxypyridinoline(Dpd)in each group were detected by double energy X-ray(DEXA),RIA and ELISA. Results] Qianggu Dan can obviously increase the level of BMD,BMC and serum E2 and reduce TRACP5b and Dpd in serum.It can also lower the content of BGP. Conclusion] Qianggu Dan may inhibit bone absorption,lower the rate of the bone transformation,and reduce the bone losing by regulating the function of cor-relative endocrine glands,so has a significant preventive and curative effect on postmenopausal osteoporosis.
Keywords:Qinggu Dan  postmenopausal osteoporosis  bone metabolism  
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