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定痫丸联合丙戊酸钠片治疗癫痫病随机平行对照研究
引用本文:姚志浩,高觉民.定痫丸联合丙戊酸钠片治疗癫痫病随机平行对照研究[J].实用中医内科杂志,2014(4):104-106.
作者姓名:姚志浩  高觉民
作者单位:南京中医药大学研究生院2012级,南京210023
摘    要:目的]观察定痫丸联合丙戊酸钠片治疗癫痫病疗效。方法]使用随机平行对照方法,将126例住院及门诊患者按随机数字表法分为两组。对照组64例丙戊酸钠,0.2g/次,3次/d,口服。治疗组62例定痫丸(明天麻、川贝母、半夏姜汁炒、茯苓蒸、茯神去木,蒸各30g,胆南星酒制、石菖蒲石杵碎,取粉、全蝎去尾,甘草水洗、僵蚕甘草水洗去嘴,炒、真琥珀腐煮,灯草研各15g,陈皮洗,去白、远志去心,甘草水洗各21g,丹参酒蒸、麦冬去心各60g,辰砂细研,水飞、人参各9g,共为细末,甘草120g熬膏,加竹沥100mL,姜汁50g,和匀调药为小丸,(每粒小丸约0.5g),4g/次,早晚口服;丙戊酸钠片,0.1g/次,3次/d,口服。连续治疗90d为1疗程。观测临床症状、不良反应。治疗1疗程,判定疗效。结果]癫痫发作频率,治疗组痊愈32例,显效42例,有效18例,无效1例,总有效率98.36%;对照组痊愈22例,显效32例,有效23例,无效8例,总有效率87.30%。癫痫发作程度积分,治疗组痊愈36例,显效45例,有效15例,无效1例,总有效率98.36%。对照组痊愈28例,显效38例,有效19例,无效6例,总有效率90.48%。治疗组疗效优于对照组(P0.05)。结论]定痫丸联合丙戊酸钠片治疗癫痫病效果显著,值得推广。

关 键 词:癫痫病  定痫丸  丙戊酸钠片  随机平行对照研究

Parallel Randomized Controlled Study of Epilepsy Pill Given Valproate Tablets Combined Therapy
Authors:YAO Zhihao  GAO Juemin
Institution:g ( Graduate School of Nanjing University of Chinese Medicine 2012, Nanjing 210023, China )
Abstract: Objective ] Given pill combined effect of sodium valproate tablets in the treatment of epilepsy. Methods ] Random parallel control method, 126 cases hospitalized and outpatients were randomly divided into two groups. The control group 64 cases of anti-epileptic medicine ( AEDs ), sodium valproate tablets, 0.2g / time, 3 times / d, orally. Treatment group of 62 patients given pill ( Mingtianma, Chuanbeimu, fried ginger Banxia, Fuling steamed, Fushen to wood, steam the 30g, Dannanxing restrained, Shichangpu crushed stone pestle, take flour, Quanxie to tail, licorice wash, Jiangcan licorice to mouth wash, fried, boiled rot Zhenhupo, Dengcao research the 15g, Chenpi wash, go white, Yuanzhi to the heart, licorice washing each 21g, Danshen Steamed, Maidong to the heart of each 60g, Chensha fine grind, water fly, Renshen each 9g, for a total fine, with Gancao 120g Aogao, plus Zhuli 100mL, Jiangzhi 50g ), and the drug is absorbed tune pellets ( each pellet about 0.5g ), 4g / times, sooner or later orally;valproate tablets, 0.1g / time, 3 times / d, orally. 90d is a continuous course of treatment. Observing clinical symptoms of adverse reactions. A course of treatment to determine efficacy. Results ] In seizure frequency in the treatment group cured 32 cases, effective in 42 cases, effective in 18 cases, one case, the total efficiency of 98.36%;control group cured 22 cases, effective in 32 cases, effective in 23 cases, 8 cases The total efficiency of 87.30%. On the seizure severity score improvement, the treatment group recovered 36 cases, effective in 45 cases, effective in 15 cases, one case, the total efficiency of 98.36%. Cured 28 cases in the control group, 38 cases markedly effective in 19 cases, six cases, the total efficiency of 90.48%. Treatment group than the control group ( P 〈0.05 ) . Conclusion ] Given pill valproate tablets in the treatment of epilepsy combined effect is remarkable, worthy of oromotion.
Keywords:Epilepsy  Given pill  Valproate tablets  Randomized parallel group study
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