糖脂平对胰岛素抵抗大鼠影响的研究 |
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引用本文: | 刘桂芳,高彦彬,林长青,王娣,张森.糖脂平对胰岛素抵抗大鼠影响的研究[J].实用中医内科杂志,2009,23(5):7-8. |
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作者姓名: | 刘桂芳 高彦彬 林长青 王娣 张森 |
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作者单位: | 北京中医药大学东方医院,北京,100029 |
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摘 要: | 目的]研究糖脂平对胰岛素抵抗大鼠的影响。方法]SD大鼠40只,随机取10只为对照组,30只为高脂组(分为糖脂平组、罗格列酮组、模型组)。对照组给予普通饮食,高脂组给予高脂饲料喂养,8周后进行高胰岛素-正糖钳夹实验,通过葡萄糖灌流速度M值来评价糖脂平对IR的影响,并测量收缩压、血脂、空腹血糖、体重。结果]糖脂平组的葡萄糖灌流速度较模型组显著降低(P〈0.05),并与罗格列酮组、对照组相比无显著差异(P〉0.05)。结论]糖脂平胶囊可降低胰岛素抵抗。
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关 键 词: | 胰岛素抵抗 糖脂平 高胰岛素-正糖钳夹技术 |
Tangzhiping Impact on Insuμlin Resistance in Rat Study |
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Authors: | Liu Gui-fang Gao Yan-bin Lin Chang-qing Wang Di Zhang Shen |
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Institution: | Liu Gui - fang, Gao Yan - bin, Lin Chang - qing, Wang Di, Zhang Shen ( Beijing University of Chinese Medicine Oriental Hospital, Beijing 100029, China) |
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Abstract: | Objective] To investigate the influence of Tangzhiping on insulin resistance in high fat diet rat. Methods ] 40 male Sprague - dawley rats were divided into four groups randomLy : control group, model group, Tangzhiping group and rosiglitazone group. The rats in control group were fed with normal diet, the other there groups were high fat diet, for 8 weeks to induce R rats model, then eugly - cemic hyperinsulinemic glucose clamp techniquewas performed to evaluate Tangshiping's effect on IR by M, and SP, blood fat, FBS ,weight were observed. Results ] Tangzhiping's Mwas decreased significantly (P 〈 0.05 ) , and no significant difference compared with control group and rosiglitazone group ( P 〉 0.05 ). Conclusion ] Tangshiping can improve insuIin resistance in high fat diet rat. |
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Keywords: | insulin resistance Tangzhiping euglycemic hyperinsulinemic glucose clamp |
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