参麦注射液联合西药治疗慢性萎缩性胃炎红细胞免疫功能改善相关性研究

目的]观察参麦注射液联合西药治疗慢性萎缩性胃炎红细胞免疫功能改善相关性。方法]使用前瞻性设计方法,将50例住院患者,在泰安市中医医院健康体检者中选择健康对照组35例。健康对照组35例停用一切影响免疫功能药物半个月以上。治疗组50例参麦注射液40m L+5%葡萄糖200m L静滴,1次/d,一般支持治疗,胃黏膜屏障功能加麦滋林-S、硫糖铝;胃排空低下加多潘立酮、莫沙必利;胃酸分泌过多加奥美拉唑和法莫替丁等;CAG合并Hp加胶态铋、抗生素、甲硝唑等。连续治疗14d为1疗程。观测红细胞C3b受体花环率(RBC-C3b RR)、免疫复合物花环率(RBC-ICR)、不良反应。治疗1疗程,判定疗效。结果]治疗组C3b RR低于对照组(P0.01,P0.05),Hp阳性低于Hp阴性、健康对照组(P0.01),治疗组RBC-ICR高于对照组(P0.01,P0.05),Hp阴性组低于Hp阳性(P0.01)。结论]参麦注射液联合西药治疗可明显改善红细胞免疫功能,疗效满意,无严重不良反应,值得推广。

Shenmai Injection combined with Western Medicine in the Treatment of Red Blood Cell Immune Function in Chronic Atrophic Gastritis to Improve Correlation Study

Objective ] To observe the effect of Shenmai injection combined with western medicine in the treatment of red blood cell immune function in chronic atrophic gastritis to improve correlation. Method ] Using a prospective design method, 50 hospitalized patients according to treatment sequence number is simple and randomly divided into two groups; in Tai＇an City Hospital of traditional Chinese medicine health examination in 35 cases of healthy control group. 35 healthy subjects served as control group without any affect the immune function of drugs for at least half a month or more. The treatment group of 50 cases of Shenmai injection 40mL＋5% glucose 200mL intravenous drip, 1 times/d, 14d for 1 courses. General support treatment, the gastric mucosal barrier function plus marzulene -S, sucralfate; gastric emptying low added domperidone, mosapride; excessive secretion of gastric acid plus omeprazole and famotidine in D; CAG with Hp and colloidal bismuth, antibiotic, metronidazole. Continuous treatment with 14d for 1 courses. 1 courses of treatment, observation index. Observation of erythrocyte C3b receptor rosette rate （RBC-C3bRR）, immune complex rosette rate （RBC-ICR）, adverse reaction. Results ] Than in the control group the treatment group C3bRR （P 〈 0.01, P 〈 0.05）, Hp positive, Hp negative is lower than that of healthy control group （P 〈 0.01）, gastritis group RBC-ICR was higher than that in control group （P 〈 0.01, P 〈 0.05） and Hp negative group was lower than that of Hp positive （P 〈 0.01）. Conclusion ] Shenmai injection combined with western medicine treatment can obviously improve the erythrocyte immune function, the curative effect is satisfied, no serious adverse reaction, is worth promoting.