补益肺肾活血方联合西药治疗特发性肺间质纤维化（IPF）随机平行对照研究

目的]观察补益肺肾活血方联合西药治疗特发性肺间质纤维化（IPF）疗效。方法]使用随机平行对照方法，将77例门诊患者按随机数字表法分为两组。均按国内常规治疗，并发肺部感染抗生素控制感染，低氧血症吸氧。对照组38例强的松、抗氧化剂。治疗组39例补益肺肾活血方（太子参、麦冬各15g，黄芪40g，山萸肉、浙贝、当归、川芎、赤芍、鳖甲各15g，等），1剂／d，水煎300mL，口服100mL／次，3次／d；西药治疗同对照组。连续治疗12周为1疗程。观测临床症状、生化指标、血气分析、肺功能（用力肺活量．FVC、肺一氧化碳弥散量-DLCO、动脉氧分压-PaO2）、不良反应。治疗1疗程，判定疗效。结果]治疗组显效3例，有效22例，无效10例，总有效率71．42％；对照组显效1例，有效12例，无效22例，总有效率37．14％；治疗组临床疗效优于对照组（P〈0．05）。中医证候疗效治疗组临床控制1例，显效5例，有效21例，无效8例，总有效率77．24％；对照组临床控制1例，显效1例，有效12例，无效21例，总有效率40．00％；治疗组中医证候疗效优于对照组（P〈0．05）。治疗组FVC、DLCO、PaO2均明显改善（P〈0．05）；对照组DLCO明显改善（P〈0．05），FVC、PaO2无显著变化（P〉0．05）；FVC、DLCO改善治疗组优于对照组（P〈0．05），PaO2改善两组无显著差异（P〉0．05）。结论]补益肺肾活血方联合西药治疗特发性肺间质纤维化（IPF），疗效满意，无明显副作用，值得推广。

nvigorating Lung and Kidney and Activating Blood Circulation Decoction Combined with Western Medicine in the Treatment of Idiopathic Pulmonary Interstitial Fibrosis （ IPF ） Randomized Parallel Controlled Study

Objective ] To observe of invigorating lung and kidney Huoxue Decoction Combined with western medicine in the treatment of idiopathic pulmonary interstitial fibrosis （ IPF ） effect.Observation of clinical symptoms, biochemical index, blood gas analysis, pulmonary function. Methods ] Using a randomized controlled method, 77 patients were randomly divided into two groups. 38 cases of the control group and prednisone, antioxidants. The treatment group of 39 cases of invigorating lung and kidney and promoting blood circu]ation （Taizishen , Maidong both 15g, Huangqi40g , Shanyurou , Zhehei , Danggui , Chuanxiong, Chishao , Biejia all 15g ） 1 agent/d, Water simmer in water 300mL. Oral 100mL/time, 3times /d;western medicine treatment with the control group. Continuous treatment for 12 weeks as 1 course of treatment. Observation of clinical symptoms, biochemical index, blood gas analysis, pulmonary function （ Forced vitalcapacity-FVC, Diffusion capacity of the lung for carbon monoxide-DLCO, The arterial partial pressure of oxygen-PaO2 ）, adverse reactions. 1 courses of treatment, the curative effect. Results ] The treatment group excellence were 3 cases, effective in 22 cases, invalid in 10 cases , the total efficiency of 71.42% ; the control group excellence were 1 cases, effective in 12 cases, invalid in 22 cases, the total efficiency of 37.14%. The clinical effect of treatment group was better than the control group （P〈0.05） . Effect of syndrome of traditional Chinese medicine, clinical control group 1 case, excellence in 5 cases, effective in 28 cases, invalid in 22 cases, the total efficiency of 77.24% ; control group, clinical control group 1 case, excellence in 1 case, effective in 12 cases, invalid in 21 cases, the total efficiency of 40.00%. The clinical effect of treatment group was better than the control group （P〈0.05） . The treatment group FVC, DLCO, PaO2 were significantly improved （ P〈0.05 ） ;Control group DLCO significantly improved （ P〈0.05 ）, FVC, PaO2 had no significant change （P〈0.05）, FVC, DLCO improvement in the treatment group than the control group （P〈0.05）, PaO2 improved in two groups had no significant difference （P〉0.05） . Conclusion ~ Invigorating lung and kidney and activating blood circulation decoction combined withwestern medicine in the treatment of idiopathic pulmonary interstitial fibrosis （ IPF ）, satisfactory effect, no obvious side effects, worthy of promotion.