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针刺对非胰岛素依赖性糖尿病大鼠渴中枢的作用
引用本文:刘志诚,孙凤岷,马志民,赵玫,徐放明,魏群利,朱苗花.针刺对非胰岛素依赖性糖尿病大鼠渴中枢的作用[J].中国针灸,2002,22(2):18-26.
作者姓名:刘志诚  孙凤岷  马志民  赵玫  徐放明  魏群利  朱苗花
作者单位:1. 南京中医药大学,江苏,210029
2. 南京人口管理干部学院
基金项目:国家自然科学基金资助项目 (№ 3 9770 92 9)
摘    要:目的:探讨针刺对非胰岛素依赖性糖尿病(NIDDM)的中枢神经作用机制。方法:采用神经电生理和生化技术观察针刺治疗前后NIDDM大鼠的变化。结果:NIDDM大鼠空腹血糖(FBS),空腹胰岛素(FINS)和渴中枢神经细胞自发放电频率及去甲肾上腺素(NA)、多巴胺(DA)含量明显高于正常大鼠,而胰岛素敏感性指数(IAI)水平明显低于正常大鼠。针刺治疗后NIDDM大鼠FBS、FINS和渴中枢神经细胞自发放电频率及NA和DA含量均明显回降,而IAI水平明显加升。渴中枢神经细胞自发放电频率与FBS呈高度正相关,与FINS呈中度正相关,与IAI呈高负负相关。结论:针刺对NIDDM大鼠渴中枢的调整作用可能是纠正胰岛素抵抗(IR),调整其异常内分泌代谢的一个重要环节。

关 键 词:针刺治疗  非胰岛素依赖性糖尿病  渴中枢  神经细胞自发放电  神经递质  NIDDM
文章编号:0255-2930(2002)02-0121-04
修稿时间:2001年2月17日

Effect of Acupuncture on the Hypothalamic Thirsty Center in Non-insulin-dependent Diabetic Rats
Liu Zhicheng ,Sun Fengmin ,Ma Zhimin ,et al.Effect of Acupuncture on the Hypothalamic Thirsty Center in Non-insulin-dependent Diabetic Rats[J].Chinese Acupuncture & Moxibustion,2002,22(2):18-26.
Authors:Liu Zhicheng  Sun Fengmin  Ma Zhimin  
Institution:Liu Zhicheng 1,Sun Fengmin 2,Ma Zhimin 1,et al
Abstract:Objective To investigate the central mechanisms of acupuncture on non?insulin?dependent diabetes mellitus (NIDDM) Methods Electrophysiological and biochemical indices were observed before and after acupuncture in NIDDM rats and compared with those in the controls Results The fasting blood sugar (FBS), fasting insulin level (FINS), neuronal spontaneous discharges in the thirsty center(NSD), noradrenaline (NA) and dopamine (DA) levels in NIDDM rats were all obviously higher than those in normal rats, while the insulin active index (IAI) was markedly lower After acupuncture treatments the levels of FBS, FINS, NSD, NA and DA in NIDDM rats were significantly lowered, while the IAI level markedly elevated NSD was positively related with FBS to a great extent, with FINS to a moderate extent, but was negatively related with IAI to a great extent Conclusion The regulative function on the thirsty center in NIDDM rats in correcting insulin resistance and balancing the abnormal endocrine metabolism may be one of the important mechanisms of acupuncture in treating NIDDM
Keywords:Acupuncture  Non?insulin?dependent Diabetes Mellitus (NIDDM)  Thirsty Center  Neuronal Spontaneous Discharges  Neurotransmitters
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