电针对完全弗氏佐剂性小鼠外周慢性炎症痛的缓解作用

目的：探讨针刺镇痛的作用规律及其穴位作用的特异性。方法：成年雄性昆明小鼠随机分为对照组、模型组、模型加电针组和模型加假电针组，将完全弗氏佐剂（CFA）注入小鼠右后脚掌形成慢性炎症痛模型，采用辐射热缩爪潜伏期（PWL）作为痛阈指标，观察造模并给予电针治疗后PWL的变化。结果：造模后，致炎侧PWL明显缩短（P〈0．05）；电针双侧“足三里”和“昆仑”穴，能明显翻转缩短的PWL（P〈0．05），且该效应随电针次数增加而延长，而假电针组PWL无明显变化；电针双侧“手三里”和“内关”穴不能翻转缩短的PWL（P〉0．05）。结论：电针镇痛作用随针刺次数增加而增强，并在一定程度上呈穴位特异性。

Electroacupuncture alleviates complete Freund's adjuvant peripheral chronic inflammatory pain in mice

OBJECTIVE: To probe into the law of acupuncture analgesic effect and specificities of acupoint action. METHODS: Adult male Kunming mice were randomly divided into a control group, a model group, a model plus electroacupuncture (EA) group and a model plus sham EA group. Chronic inflammatory pain model was prepared by injection of complete Freund's adjuvant (CFA) into right posterior foot, and paw withdrawing latency (PWL) induced by radiation heat was used as pain threshold index, and changes of PWL in all the groups were investigated. RESULTS: After modeling, PWL significantly shortened on the inflammatory side (P < 0.05); EA at bilateral "Zusanli" (ST 36) and "Kunlun" (BL 60) could significantly reverse the shortened PWL (P < 0.05), and this effect was prolonged along with increase of EA times, but in the sham EA group PWL did not significantly change; EA at bilateral "Shousanli" (LI 10) and Neiguan" (PC 6) could not reverse the shortened PWL (P > 0.05). CONCLUSION: Analgesic effect of EA is strengthened along with increase of EA times and shows specificity of acupoints to a certain extent.