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穴位处胶原纤维在针刺大鼠"足三里"镇痛过程中的作用
引用本文:余晓佳,丁光宏,姚伟,詹睿,黄猛.穴位处胶原纤维在针刺大鼠"足三里"镇痛过程中的作用[J].中国针灸,2008,28(3):207-213.
作者姓名:余晓佳  丁光宏  姚伟  詹睿  黄猛
作者单位:1. 复旦大学力学与工程科学系,上海,200433
2. 上海市针灸经络研究中心
基金项目:国家重点基础研究发展计划(973计划) , 上海市科技发展基金 , 上海市教委资助项目
摘    要:目的:探讨针刺镇痛作用机制。方法:采用穴位注射Ⅰ型胶原酶法破坏穴区胶原组织结构。在急性佐剂关节炎大鼠模型上,以大鼠缩爪反射的潜伏期及肥大细胞脱颗粒率为观察指标,比较破坏与不破坏穴位区胶原组织结构2种情况下,针刺“足三里”捻转或提插手法对针刺镇痛效应及肥大细胞的影响。结果:破坏胶原结构后2种手法的镇痛效果明显削弱,且穴位肥大细胞脱颗粒也受到明显抑制。结论:穴区胶原纤维与肥大细胞在针刺镇痛效应的产生过程中起到了重要的作用,胶原纤维参与了针刺信号由穴位向靶器官传输与转换过程,而肥大细胞脱颗粒则始终与针刺镇痛效应呈正相关。

关 键 词:  足三里  针刺镇痛原理  纤维素体/针灸效应  肥大细胞/针灸效应  大鼠  穴位区  胶原纤维  针刺信号  大鼠模型  足三里  镇痛效果  转换过程  作用  fiber  collagen  role  Zusanli  analgesia  相关  传输  靶器官  位向  产生过程  原结构  结果
文章编号:0255-2930(2008)03-0207-07
修稿时间:2007年3月30日

The role of collagen fiber in "Zusanli" (ST 36) in acupuncture analgesia in the rat
YU Xiao-jia,DING Guang-hong,YAO Wei,ZHAN Rui,HUANG Meng.The role of collagen fiber in "Zusanli" (ST 36) in acupuncture analgesia in the rat[J].Chinese Acupuncture & Moxibustion,2008,28(3):207-213.
Authors:YU Xiao-jia  DING Guang-hong  YAO Wei  ZHAN Rui  HUANG Meng
Institution:Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433, China.
Abstract:OBJECTIVE: To probe into the mechanism of acupuncture analgesia. METHODS: Type-I collagenase was injected to destroy the structure of collagen fibers in the acupoint. Paw withdrawing latency and mast cell degranulation rate in the acute adjuvant arthritis rat were investigated. Effects of acupuncture at "Zusanli" (ST 36) with twirling or thrusting-lifting manipulation on acupuncture analgesia and mast cells were compared when the structures of collagen fibers in the acupoint were destroyed or not. RESULTS: When the structures of collagen fiber were destroyed, the analgesic effects of both acupuncture manipulations were attenuated and the degranulation rate of mast cells caused by acupuncture were significantly inhibited. CONCLUSION: Collagen fibers and mast cells in the acupoint play an important role in acupuncture analgesia. Collagen fibers participate in transmission and transform process of acupuncture signs from the acupoint to the target organ, and the degranulation of mast cells is positively correlated with acupuncture analgesia.
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