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耳穴埋针对血管性痴呆大鼠记忆障碍及β淀粉样蛋白表达的影响
引用本文:卢雨微,吕明庄,贺志光.耳穴埋针对血管性痴呆大鼠记忆障碍及β淀粉样蛋白表达的影响[J].中国针灸,2006,26(11):804-808.
作者姓名:卢雨微  吕明庄  贺志光
作者单位:贵阳医学院附属医院针灸科,贵州,550004
摘    要:目的:探讨耳穴改善血管性痴呆(VD)大鼠学习记忆障碍的反应机制。方法:采用4-血管阻断(4-Vesselocclusion,4-VO)全脑缺血再灌注制备VD大鼠模型,随机分为假手术组、正常对照组、模型组、耳针组,针刺耳穴脑、肾后,做免疫组化、行为学检测、图像分析。结果:耳针能显著降低VD模型大鼠脑内顶叶皮层Aβ免疫阳性神经元的细胞数,升高其平均光密度值(P<0·05)。结论:耳针能减少或抑制Aβ的过度产生,这可能是减少了Aβ的沉积,阻止Aβ装备成有毒性的聚合体,保护神经元免受Aβ的神经毒性,从而改善VD模型大鼠学习记忆。

关 键 词:痴呆  血管性/穴位疗法  埋针  皮内针  耳针  淀粉样β蛋白/针灸效应
文章编号:0255-2930(2006)11-0804-04
收稿时间:2006-02-16
修稿时间:2006年2月16日

Effects of ear point needle embedding therapy on memory disorder and expression of β-amyloid protein in the rat of vascular dementia
LU Yu-wei,L Ming-zhuang,HE Zhi-guang.Effects of ear point needle embedding therapy on memory disorder and expression of β-amyloid protein in the rat of vascular dementia[J].Chinese Acupuncture & Moxibustion,2006,26(11):804-808.
Authors:LU Yu-wei  L Ming-zhuang  HE Zhi-guang
Institution:Affiliated Hospital of Guiyang Medical College, Guizhou 550004, China
Abstract:OBJECTIVE: To study the mechanism of auricular acupuncture for improvement of learning and memory disorders in the rat of vascular dementia (VD). METHODS: The vascular dementia rat model was made by 4-vessel occlusion method. Four groups, a sham operation group, a normal control group, a model group and an auricular acupuncture group were set up. After acupuncture was given at auricular points, Brain and Kidney. Immunohistochemical analysis, behavioural observation and computer image analysis were made. RESULTS: Auricular acupuncture could decrease significantly the beta-amyloid protein (A beta) immunoreactivive neurons and increase its average optical density in the parietal cortex of the VD rats (P < 0.05). CONCLUSION: Auricular acupuncture can reduce or inhibit the over-production of Abeta in the brain, so as to improve the learning and memory capacity of the VD model rat.
Keywords:Dementia  Vascular/acupoint  Embedding  Intradermal Needle  Auricular Acupuncture  Amyloid Beta-Protein/acup-mox eff
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