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艾灸抗炎免疫作用中松果腺褪黑素高位调节的研究
引用本文:唐照亮,宋小鸽,李俊,金涌,陈全珠,侯正明,章复清,袁静,陈向涛,张道芹,许冠荪,徐叔云.艾灸抗炎免疫作用中松果腺褪黑素高位调节的研究[J].中国针灸,2001,21(7):429-431.
作者姓名:唐照亮  宋小鸽  李俊  金涌  陈全珠  侯正明  章复清  袁静  陈向涛  张道芹  许冠荪  徐叔云
作者单位:1. 安徽中医学院针灸经络研究所,
2. 安徽医科大学临床药理研究所
基金项目:国家自然科学基金课题(№.39670903),江苏省针灸学重点开放实验室资助
摘    要:目的研究松果腺褪黑素(MT)对炎症与免疫的调节,探讨艾灸抗炎免疫作用的机理.方法建立佐剂性关节炎大鼠模型,分别损毁其海马内NA神经和摘除肾上腺,观察艾灸对MT及细胞因子IL-6、IL-2的影响.结果艾灸"肾俞"穴能恢复和促进大鼠MT的分泌,使IL-6降低、IL-2升高,与对照组比较差异显著(P<0.05,P<0.01).失去肾上腺和海马交感神经的支配,松果腺MT增多,IL-6、IL-2含量上升,灸疗的抗炎免疫作用被削弱或部分阻断.结论提示松果腺MT参与艾灸抗炎免疫作用的高位调节.

关 键 词:松果体  针灸效应  分泌  褪黑激素  艾条灸
文章编号:0255-2930(2001)07-0429-03
修稿时间:2000年7月16日

Study on Effects of Conarial Melatonin on Anti-Inflammatory and Immune Actions of Moxibustion
Tang Zhaoliang ,Song Xiaoge ,Li Jun ,et al.Study on Effects of Conarial Melatonin on Anti-Inflammatory and Immune Actions of Moxibustion[J].Chinese Acupuncture & Moxibustion,2001,21(7):429-431.
Authors:Tang Zhaoliang  Song Xiaoge  Li Jun  et al
Institution:Tang Zhaoliang 1,Song Xiaoge 1,Li Jun 2,et al
Abstract:Purpose To observe action of conarial melatonin(MT)in regulation of anti inflammation and immunity for studing the mechanism of moxibustion.Methods Adjuvant arthritis model rat was established and noradrenergic neurons in hippocampus were destroyed and adrenal gland was removed,and then the effects of moxibustion on MT,IL 6 and IL 2 were observed.Results Moxibustion at Shenshu(BL 23)promoted secretion of MT,reduced IL 6 level and increased IL 2 content,with significant differences as compared with that of the control group respectively ( P<0 05,P<0 01 ).When adrenal gland was removed and noradrenergic neurons were dystroyed,conarial MT,IL 6 and IL 2 contents increased,and anti inflammatory and immunologic action of moxibustion were decreased or partially abolished.Conclusion Conarial MT may be involved in regulation of anti inflammatory and immune actions of moxibustion.
Keywords:Pineal  Body/acup  eff  Pineal  Body/secret  Melatonin/secret  Moxa  Stick  Moxibustion
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