| 三步序贯法对激素依赖型哮喘患者下丘脑-垂体-肾上腺皮质轴功能及糖皮质激素受体的影响 |
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| 引用本文： | 崔红生,徐光勋,王硕仁,周冠芬.三步序贯法对激素依赖型哮喘患者下丘脑-垂体-肾上腺皮质轴功能及糖皮质激素受体的影响[J].中华中医药杂志,2008,23(11):961-964. |
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| 作者姓名： | 崔红生 徐光勋 王硕仁 周冠芬 |
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| 作者单位： | [1]北京中医药大学东直门医院,北京100700 [2]首都医科大学附属北京中医医院,北京100010 |
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| 摘 要： | 目的:观察三步序贯法对激素依赖型哮喘患者下丘脑-垂体-肾上腺皮质(hypothalamic-pituitary-adrenal,HPA)轴功能及糖皮质激素受体(glucocorticoid receptor,GCR)的影响.方法:将入选病例按随机数字表分为治疗组29例和对照组26例.在逐渐撤减泼尼松量的过程中,对照组予普米克都保(布地奈德粉吸入剂,100μg/吸),每次400μg,每日2次吸入;治疗组予中药三步序贯方煎剂,每次100ml,每日2次口服,同时给予普米克都保200μg,每日2次吸入.两组疗程均12-14周.观察治疗前后血浆皮质醇(cortisol,COR),促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)以及外周血单个核细胞(Peripheral blood mononuclear cell,PBMC)GCR数目的变化.结果:两组患者血浆ACTH和COR浓度以及PBMC GCR水平较治疗前均明显升高,且两组之间比较差异均具有显著性(P均＜0.05).结论:三步序贯法能够恢复SDA患者被抑制的HPA轴功能,上调PBMC GCR水平,从而具有减轻全身性不良反应,增强糖皮质激素的敏感性,减轻激素依赖的作用.
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| 关 键 词： | 激素依赖型哮喘 三步序贯法 HPA轴 糖皮质激素受体 |
Effect of three-stage sequential therapy on the functions of hypothalamic-pituitary-adrenal axis and levels of the glucocorticoid receptor in patients with steroid-dependent asthma |
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| CUI Hong-sheng,XU Guang-xun,WANG Shuo-ren,ZHOU Guan-fen.Effect of three-stage sequential therapy on the functions of hypothalamic-pituitary-adrenal axis and levels of the glucocorticoid receptor in patients with steroid-dependent asthma[J].China Journal of Traditional Chinese Medicine and Pharmacy,2008,23(11):961-964. |
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| Authors: | CUI Hong-sheng XU Guang-xun WANG Shuo-ren ZHOU Guan-fen |
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| Institution: | CUI Hong-sheng1,XU Guang-xun2,WANG Shuo-ren1,ZHOU Guan-fen1 (1Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China,2Beijing Hospital of TCM Affiliated to Capital Medical University,Beijing 100010,China) |
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| Abstract: | |
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| Keywords: | Steroid-dependent asthma Three-stage sequential therapy HPA GCR |
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