| 脊髓胶质细胞——电针镇痛研究新靶点 |
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| 引用本文： | 梁宜,方剑乔,刘喆,邵晓梅.脊髓胶质细胞——电针镇痛研究新靶点[J].中华中医药杂志,2012(2):444-447. |
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| 作者姓名： | 梁宜 方剑乔 刘喆 邵晓梅 |
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| 作者单位： | 浙江中医药大学第三临床医学院;浙江中医药大学附属第三医院 |
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| 基金项目： | 浙江省自然科学基金(No.Y2091151);浙江省中医药科技计划(No.2009YA012);浙江省“重中之重”学科(针灸推拿学)建设经费(No.浙教高科[2008]255号)~~ |
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| 摘 要： | 新近发现,脊髓胶质细胞活化与病理性疼痛的发生和维持密切相关,突破了人们对疼痛发生和维持的传统观念——仅有神经元参与。体内和体外研究都提示电针可干预脊髓胶质细胞活化,且抑制胶质细胞活化可协同电针镇痛作用,因此认为脊髓胶质细胞及其与神经元构建的网络系统可能成为电针镇痛研究的又一新靶点。
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| 关 键 词： | 胶质细胞 病理性疼痛 电针镇痛 |
Spinal glial cells:new target spot of electroacupuncture analgesia research |
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| LIANG Yi,FANG Jian-qiao,LIU Zhe,SHAO Xiao-mei.Spinal glial cells:new target spot of electroacupuncture analgesia research[J].China Journal of Traditional Chinese Medicine and Pharmacy,2012(2):444-447. |
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| Authors: | LIANG Yi FANG Jian-qiao LIU Zhe SHAO Xiao-mei |
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| Institution: | LIANG Yi1,2,FANG Jian-qiao1,2,LIU Zhe1,SHAO Xiao-mei1(1The Third Clinical Medical College,Zhejiang University of Chinese Medicine,Hangzhou 310053,China;2The Third Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310009,China) |
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| Abstract: | Recent studies have been reported that activation of spinal glial cell is associated with the initiation and maintenance of pathological pain,which are different to the traditional recognization of the generation and maintenance of pain—only neuron involved.Researches in vivo and in vitro shows that electroacupuncture(EA) can intervene the activation of spinal glial cells,moreover,inhibiting activation of glial cells synergizes EA analgesia.It is considered that spinal glial cells,in other words the neural-glial network,might be new target spot of EA analgesia research. |
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| Keywords: | Glial cell Pathological pain Electroacupuncture analgesia |
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