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咳喘宁对支气管哮喘大鼠肺组织一氧化氮和内皮素-1含量的影响
引用本文:王晓红,杨牧祥,于文涛,徐华洲,段旭东. 咳喘宁对支气管哮喘大鼠肺组织一氧化氮和内皮素-1含量的影响[J]. 中华中医药杂志, 2007, 22(1): 12-15
作者姓名:王晓红  杨牧祥  于文涛  徐华洲  段旭东
作者单位:1. 河北医科大学第二医院,石家庄,050000
2. 河北医科大学中医学院,石家庄,050091
摘    要:目的:观察咳喘宁对支气管哮喘大鼠肺组织一氧化氮(NO)和内皮素(ET-1)含量的影响。方法:40只SD大鼠随机分为正常组、模型组、咳喘宁高剂量组(27g生药/kg体质量)、咳喘宁低剂量组(13.5g生药/kg体质量)、桂龙咳喘宁组(0.41g/kg体质量),每组8只。除正常组外以卵蛋白致敏并吸入激发法制备大鼠支气管哮喘模型,各治疗组均从第1次哮喘激发开始(造模第3周)至处死前每天灌胃给药,激发并给药4周后处死大鼠,观察肺组织NO、ET-1含量和病理组织学变化。结果:与正常组比较,模型组大鼠支气管管壁和平滑肌厚度、嗜酸性粒细胞、淋巴细胞数以及肺组织NO、ET-1含量明显增加(P〈0.01);与模型组比较,各治疗组均可显著降低支气管管壁和平滑肌厚度、嗜酸性粒细胞、淋巴细胞数以及肺组织NO、ET-1含量(P〈0.05或P〈0.01);且咳喘宁高、低剂量组优于桂龙咳喘宁胶囊组(P〈0.05或P〈0.01)。结论:咳喘宁可通过降低肺组织NO和ET-1含量,抑制支气管哮喘大鼠气道炎症和气道重塑等病理过程。

关 键 词:咳喘宁  支气管哮喘  一氧化氮  内皮素
修稿时间:2006-08-04

Effects of Kechuanning on NO and ET-1 in Lung Tissue of Rat with Bronchial Asthma
Wang Xiaohong,Yang Muxiang,Yu Wentao,Xu Huazhou,Duan Xudong. Effects of Kechuanning on NO and ET-1 in Lung Tissue of Rat with Bronchial Asthma[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2007, 22(1): 12-15
Authors:Wang Xiaohong  Yang Muxiang  Yu Wentao  Xu Huazhou  Duan Xudong
Affiliation:1The Second Afeared Hospital of Hebei Medical University, Shijiazhuaag 050000; 2Traditional Chinese Medical College, Hebei Medical University, Shijiazhuang 050091
Abstract:Objective: To observe the effects of Kechuanning on nitrogen monoxidum(NO) and endothelin(ET-1) of in pulmonary tissue of rat with bronchial asthma. Methods: 40 rats were randomly divided into 5 groups: the normal group,the model group,Kechuanning high-dose group(27g/kg),Kechuanning low-dose group (13.5g/kg) and Guilong Kechuanning Capsule control group(0.41g/kg),8 rats each group.The bronchial asthmatic model was established by egg protein sensibilization and long-term inhalation provocation.The rats of each treatment groups were given intragastric administration each day from the first time of provocation to execution.After 4 weeks of treatment,the rats were killed and lung tissue were taken to dyeing of HE to be observed.The contents of NO and ET-1 in lung tissue were determined.Results: Compared with the normal group,the thickness of bronchus wall and bronchus smooth muscle,the numbers of eosinophile granulocyte and leukomonocyte,and the contents of NO and ET-1 in lung tissue were increased in the model group(P(<0.01));Compared with the model group,the thickness of bronchus wall and bronchus smooth muscle,the numbers of eosinophile granulocyte and leukomonocyte and the contents of NO and ET-1 in lung tissue were decreased in the each treatment group(P<0.05 or P<0.01);And Kechuanning high-dose and low-dose groups surpass Guilong Kechuanning Capsule group(P<(0.05) or P<0.01).Conclusion: Kechuanning could decrease the contents of NO and ET-1 in lung tissue,so as to restrain air passage inflammation and against airway remolding.
Keywords:Kechuanning  bronchial asthma  nitrogen monoxidum(NO)  endothelin(ET-1)
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