| 冠心病痰瘀辨证与相关炎症标志物关系初探 |
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| 引用本文： | 刘艳,叶武,王坤根,毛威,华军益,蔡宏文,陈杰,陈隽妍,许志良.冠心病痰瘀辨证与相关炎症标志物关系初探[J].中华中医药杂志,2008,23(12):1121-1124. |
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| 作者姓名： | 刘艳 叶武 王坤根 毛威 华军益 蔡宏文 陈杰 陈隽妍 许志良 |
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| 作者单位： | [1]浙江中医药大学附属第一临床医学院浙江省中医院,杭州310006 [2]浙江中医药大学,杭州310053 |
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| 基金项目： | 浙江省科技攻关计划项目(No.2007C33022) |
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| 摘 要： | 目的:探讨冠心病(胸痹)痰瘀辨证与炎症标志物超敏C反应蛋白(high-sensitivity C-reactive protein,hsCRP)、可溶性CD40配体(soluble CD40 ligand,aCD40L)表达的关系.方法:入选60例冠心病患者,分为非痰非瘀组(n=20),痰凝心脉组(n=20),痰瘀互结组(n=20).另选健康志愿者作为正常对照(n=20),免疫透射比浊法测hsCRP,酶联免疫吸附(ELISA)法测血清aCD40L水平.结果:与正常对照组比,非痰非瘀组、痰凝心脉组和痰瘀互结组患者血清ha-CRP和sCD40L水平均升高(P＜0.05或P＜0.01);与非痰非瘀组比较,痰凝心脉组及痰瘀互结组患者血清ha-CRP水平逐渐升高(P＜0.05或P＜0.01),且二者之间的差异具有统计学意义(P＜0.01),而血清sCD40L水平略高于非痰非瘀组(P＞0.05),且两组间的差异没有统计学意义(P＞0.05).相关性分析可见,血清hs-CRP水平与冠心病痰瘀辨证之间有相关性(P＜0.05或P＜0.01).结论:血清炎症标志物ha-CRP水平可为冠心病痰瘀辨证分型提供客观依据.
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| 关 键 词： | 冠心病 痰瘀辨证 超敏C反应蛋白 可溶性CD40配体 |
Study on relationship between phlegm stasis syndrom differentiation and corresponding inflammatory markers of coronary heart disease |
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| LIU Yan,YE Wu,WANG Kun-gen,MAO Wei,HUA Jun-yi,CAI Hong-wen,CHEN Jie,CHEN Jun-yan,XU Zhi-liang.Study on relationship between phlegm stasis syndrom differentiation and corresponding inflammatory markers of coronary heart disease[J].China Journal of Traditional Chinese Medicine and Pharmacy,2008,23(12):1121-1124. |
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| Authors: | LIU Yan YE Wu WANG Kun-gen MAO Wei HUA Jun-yi CAI Hong-wen CHEN Jie CHEN Jun-yan XU Zhi-liang |
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| Institution: | LIU Yan1,YE Wu1,WANG Kun-gen1,MAO Wei1,HUA Jun-yi1,CAI Hong-wen1,CHEN Jie2,CHEN Jun-yan2,XU Zhi-liang1(1The First Clinical Medical School of Zhejiang Chinese Medical University,Zhejiang Provincial Hospital of TCM,Hangzhou 310006,China,2Zhejiang Chinese Medical University,Hangzhou 310053,China) |
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| Abstract: | Objective:To explore the relationship between syndrome differentiation of phlegm and blood stasis of coronary heart disease and the levels of high-sensitivity C-reactive protein(hs-CRP)and soluble CD40 ligand(sCD40L).Methods:Sixty patients with coronary heart disease were evenly divided into three groups randomly:the non-phlegm and non-stasis group(n=20),the congealing phlegm of heart vessels group(n=20)and the intermingled phlegm and blood stasis group(n=20).Twenty healthy volunteers was as the control gro... |
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| Keywords: | Coronary heart disease Syndrome differentiation of phlegm and blood stasis High-sensitivity C-reactive protein Soluble CD40 ligand |
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