| 肝郁型黄褐斑小鼠模型的建立及其与现有模型的比较研究 |
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| 引用本文： | 汪南玥,陈家旭,吴晓丹.肝郁型黄褐斑小鼠模型的建立及其与现有模型的比较研究[J].中华中医药杂志,2007,22(5):325-327. |
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| 作者姓名： | 汪南玥 陈家旭 吴晓丹 |
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| 作者单位： | 北京中医药大学,北京,100029 |
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| 摘 要： | 目的：建立并验证肝郁型黄褐斑小鼠模型，并与现有其他模型进行比较。方法：注射黄体酮同时，进行慢性束缚和紫外线局部照射。结果：黄体酮＋紫外线＋束缚复合法造模较其他方法更能导致皮肤丙二醛（MDA）升高和超氧化物歧化酶（SOD）降低以及皮肤黑色素细胞的增加，并且具有肝郁证的行动学表现。结论：黄体酮＋紫外线＋束缚法建立的肝郁型黄褐斑小鼠多因素模型获得成功。
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| 关 键 词： | 黄褐斑 肝郁证 小鼠模型 |
| 修稿时间： | 2006-10-28 |
Establishment of Chloasma Mouse Model with Syndrome of Liver-qi Stagnation and Comparative Study of It with Existent Models |
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| Wang Nanyue,Chen Jiaxu,Wu Xiaodan.Establishment of Chloasma Mouse Model with Syndrome of Liver-qi Stagnation and Comparative Study of It with Existent Models[J].China Journal of Traditional Chinese Medicine and Pharmacy,2007,22(5):325-327. |
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| Authors: | Wang Nanyue Chen Jiaxu Wu Xiaodan |
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| Institution: | Beijing University of Traditional Chinese Medicine, Beijing 100029 |
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| Abstract: | Objective: To establish and authenticate the chloasma mouse model with syndrome of liver-qi stagnation,and compare it with other existent models.Method: After the injection of progesterone,chronically constrained them and gave them partially ultraviolet radiation.Results: Multiple models of progesterone injection and ultraviolet radiation compounding with chronic constraint can heighten MDA,depress SOD,and increase melanocytes of skin.Meanwhile,the ethology of this model showed it's syndrome of liver-qi stagnation.Conclusion: The multiple factor chloasma mouse model of liver-qi stagnation syndrome has been built successfully. |
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| Keywords: | chloasma syndrome of liver-qi stagnation mouse model |
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