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载脂蛋白E基因多态性与高脂血症痰瘀证患者血脂水平关系的研究
引用本文:梁晋普,杨惠民,盛彤,韩丽蓓,袁玉娇,牛晓红,金红.载脂蛋白E基因多态性与高脂血症痰瘀证患者血脂水平关系的研究[J].中华中医药杂志,2008,23(7):633-635.
作者姓名:梁晋普  杨惠民  盛彤  韩丽蓓  袁玉娇  牛晓红  金红
作者单位:1. 北京中医药大学东直门医院,北京,100700
2. 北京中医药大学东方医院,北京,100078
3. 中国中医科学院中医基础研究所,北京,100700
摘    要:目的:研究载脂蛋白E(ApoE)基因多态性对高脂血症痰瘀证患者血脂水平的影响。方法:运用PCR-RFLP法检测210例高脂血症痰瘀证患者ApoE基因分型,分析ApoE基因多态性与血脂总胆固醇(TC)、甘油三酯(TG)、低密度胆固醇(LDL-C)、高密度胆固醇(HDL-C)水平的关系,结果:高脂血症痰瘀证患者不同ApoE基因型,血脂LDL-C水平,按照E3/4﹥E3/3﹥E2/3的规律逐渐降低,经比较具有显著性差异,P<0.01(P=0.0046),以E3/4为最高,E2/3为最低,而TC、TG、HDL-C水平无明显差异。结论:ApoE基因多态性影响高脂血症血脂水平,E4基因型痰瘀证个体血脂LDL-C水平明显增高,推测E4基因型可能是高脂血症痰瘀证候主要易感基因之一。

关 键 词:高脂血症  痰瘀证  载脂蛋白E基因多态性

Study on the relationship between ApoE gene polymorphism and plasma lipid levels of phlegm-blood-stasis syndrome of hyperlipemia
LIANG Jin-pu,YANG Hui-min,SHENG Tong,HAN Li-bei,YUAN Yu-jiao,NIU Xiao-hong,JIN Hong.Study on the relationship between ApoE gene polymorphism and plasma lipid levels of phlegm-blood-stasis syndrome of hyperlipemia[J].China Journal of Traditional Chinese Medicine and Pharmacy,2008,23(7):633-635.
Authors:LIANG Jin-pu  YANG Hui-min  SHENG Tong  HAN Li-bei  YUAN Yu-jiao  NIU Xiao-hong  JIN Hong
Abstract:Objective:To investigate the e ect of apolipoprotein E gene polymorphism on plasma lipid levels of phlegm-blood-stasis syndrome of hyperlipemia.Methods:The genotype of 206 patients with phlegm-blood-stasis of hyperlipemia was detected by the method of PCR-RFLP and the relationship between apolipoprotein E gene polymorphism and the level of total cholesterolTC,triglycerideTG,low density lipoprotein cholesterol(LDL-L) and high density lipoprotein cholesterol(HDL-C)was anaylized.Results The level of low density lipoprotein cholesterol(LDL-L) among the di erent apolipoprotein E genotypes in patients with phlegm-blood-stasis syndrome of hyperlipemia has extremely signi cant di erence(P<0.01,P=0.0046) by compare.The regularity is E3/4 E3/3 E2/3.The highest is E3/4 and the lowest is E2/3.The level of total cholesterol TC,triglyceride TGand high density lipoprotein cholesterol(HDL-C) has no signi cant di erence.Conclusion:Apolipoprotein E gene polymorphism in uence on plasma lipids level of hyperlipemia and the LDL-L level of phlegm-blood-stasis syndrome in E4 genotype obsviously heightens.E4 genotype may be one of the main predisposing genes in the phlegm-blood-stasis syndrome of hyperlipemia.
Keywords:Hyperlipemia  Phlegm-blood-stasis syndrome  Apolipoprotein E gene polymorphism
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