| 多指标成分含量测定与指纹图谱分析在中药制备工艺与质量控制中的应用 |
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| 引用本文： | 张萍,杨燕,鄢丹,任永申,周灿平,王晶彬,孔维军,肖小河.多指标成分含量测定与指纹图谱分析在中药制备工艺与质量控制中的应用[J].中华中医药杂志,2010(1). |
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| 作者姓名： | 张萍 杨燕 鄢丹 任永申 周灿平 王晶彬 孔维军 肖小河 |
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| 作者单位： | 解放军302医院全军中药研究所;解放军军医进修学院研究生队;成都中医药大学药学院;湖南中医药大学药学院; |
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| 基金项目： | 国家自然科学基金(No.30701109)~~ |
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| 摘 要： | 现有的以单一化学指标的变化情况来控制中药制备工艺的方法,难以体现制备过程中化学成分的整体变化情况,也很难保证中药药效物质基础的有效传递。采用多指标成分含量测定+色谱指纹图谱的控制模式,可以实现对制备工艺的全程把关,以及对产品质量的精确控制,有效保证中药的有效性和稳定性,并将成为中药质控的重要手段,具有较好的应用前景。
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| 关 键 词： | 中药 多指标成分 指纹图谱 制备工艺 质量控制 |
Application of multi-target ingredients determination and fingerprint analysis in preparation and quality control of Chinese medicine |
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| ZHANG Ping,YANG Yan,YAN Dan,REN Yong-shen,ZHOU Can-ping,WANG Jing-bin,KONG Wei-jun,XIAO Xiao-he.Application of multi-target ingredients determination and fingerprint analysis in preparation and quality control of Chinese medicine[J].China Journal of Traditional Chinese Medicine and Pharmacy,2010(1). |
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| Authors: | ZHANG Ping YANG Yan YAN Dan REN Yong-shen ZHOU Can-ping WANG Jing-bin KONG Wei-jun XIAO Xiao-he |
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| Institution: | 1Military Institute of Chinese Materia Medica;302 Miltary Hospital of China;Beijing 100039;China;2Postgraduate Team;Advanced Study School of PLA;Beijing 100853;3Pharmacy College;Chengdu University of TCM;Chengdu 611137;4College of Pharmaceutical Sciences;Hunan University of Chinese Medicine;Changsha 410208;China |
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| Abstract: | The present means of using one single ingredient in evaluating the preparation of Chinese medicine can not reflect the changes of chemical composition during the process, yet can not guarantee the transmission result of effective constituent. A new means will overcome these problems by using multi-target ingredient determination and finger printing analysis technologies, which could control the whole process in preparation and product quality precisely, and insure the stability and effectiveness of products... |
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| Keywords: | Chinese medicine Multi-target ingredient Finger printing Preparation Quality control |
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