| 拉米夫定与原儿茶酸药物组合体内抗鸭乙肝病毒 |
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| 引用本文： | 潘琪,王玲,王俊俊,陈勇,韩凤梅.拉米夫定与原儿茶酸药物组合体内抗鸭乙肝病毒[J].中华中医药杂志,2011(11):2500-2504. |
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| 作者姓名： | 潘琪 王玲 王俊俊 陈勇 韩凤梅 |
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| 作者单位： | 湖北大学中药生物技术省重点实验室; |
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| 基金项目： | 科技部重大专项(No.2008ZX10002-009); 湖北省发改委生物产业专项(No.2008-1365-2); 武汉市科技局攻关项目(No.201060623264)~~ |
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| 摘 要： | 目的:研究拉米夫定(3TC)联合原儿茶酸(PA)对鸭体内鸭乙肝病毒(DHBV)的抑制作用。方法:感染DHBV的北京雏鸭模型随机分为3TC组,PA组,3TC/PA合用组及模型对照组,每天灌胃给药1次,连续给药10天。分别于给药前、给药第5天、给药第10天及停药后第3天取血,检测血清中DHBV DNA、白蛋白(ALB)和总胆红素(TBil)含量,以及谷丙转氨酶(ALT)、谷草转氨酶(AST)和碱性磷酸酶(ALP)活性,并对各时间点肝组织进行病理形态学分析。结果:PA、3TC单用及合用对雏鸭血清DHBV DNA有抑制作用,且合用时的抑制作用最为显著,停药3天后仍与给药前有显著性差异。同时,3TC与PA合用组血清中ALT、AST和ALP活性,以及ALB和TBil含量均较模型对照组有一定程度的降低。另外,3TC组肝脏病理形态与模型对照组相比无明显改善,但PA及其与3TC合用组肝组织病理形态均有一定程度改善。结论:3TC与PA合用可有效抑制雏鸭的DHBV感染,且对DHBV所致雏鸭肝损伤有一定保护作用。
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| 关 键 词： | 鸭乙型肝炎病毒 拉米夫定 原儿茶酸 |
Anti-duck hepatitis B virus effect of lamivudine combined with protocatechuic acid in vivo |
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| PAN Qi,WANG Ling,WANG Jun-jun,CHEN Yong,HAN Feng-mei.Anti-duck hepatitis B virus effect of lamivudine combined with protocatechuic acid in vivo[J].China Journal of Traditional Chinese Medicine and Pharmacy,2011(11):2500-2504. |
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| Authors: | PAN Qi WANG Ling WANG Jun-jun CHEN Yong HAN Feng-mei |
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| Institution: | PAN Qi,WANG Ling,WANG Jun-jun,CHEN Yong,HAN Feng-mei(Hubei Province Key Laboratory of Biotechnology of Chinese Medicine,Hubei University,Wuhan 430062,China) |
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| Abstract: | Objective: To investigate the anti-duck hepatitis B virus(DHBV) effect of lamivudine(3TC) combined with protocatechuic acid(PA) in vivo in Pekin-ducks.Methods: Pekin-ducks(1-3 days age)-DHBV infection mode were randomly divided into the mode control group,3TC-treated group,PA-treated group,and 3TC plus PA treated group.After oral administration by gavage a single dose daily for 10 days,blood samples were collected by leg vein bleeding at 0,5th-,10th-day of drug administration and drug withdrawal 3th-day.The... |
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| Keywords: | Duck hepatitis B virus Lamivudine Protocatechuic acid |
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