| 中药复方松友饮抑制姑息性肝切除术后残癌生长和转移的实验研究 |
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| 引用本文： | 黄修燕,黄自丽,汤钊猷,郑起,周俭,叶胜龙. 中药复方松友饮抑制姑息性肝切除术后残癌生长和转移的实验研究[J]. 中华中医药杂志, 2010, 0(12) |
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| 作者姓名： | 黄修燕 黄自丽 汤钊猷 郑起 周俭 叶胜龙 |
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| 作者单位： | 上海交通大学附属第六人民医院;上海市徐汇区中心医院;复旦大学肝癌研究所; |
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| 基金项目： | 国家重点基础研究(973)项目(No.2004CB518708); 上海交通大学附属第六人民医院课题(No.院-1131)~~ |
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| 摘 要： | 目的:研究中药复方松友饮对姑息性肝切除裸鼠模型中残癌生长及转移的影响。方法:以人肝癌细胞(MHCC97H)建立裸鼠移植瘤姑息性肝切除模型,36只裸鼠随机分成对照组和松友饮组,每天1次灌胃给药连续5周,每周测体质量。给药结束后第2d每组处死6只裸鼠观察肿瘤大小、肺转移等;并检测残癌中白细胞介素-1β(IL-1β)和增殖细胞核抗原(PCNA)表达情况。剩余裸鼠用于观察生存期。结果:松友饮组与对照组残癌体积为(724.9±337.6)mm3和(1205.2±581.3)mm3(P<0.05),抑瘤率为39.9%;肺转移分级下降(P<0.05)。前者体质量大于对照组(P<0.001),生存期延长率为22.7%;IL-1βmRNA表达水平显著下调(P<0.001),蛋白水平为(18.0±5.1)pg/mL和(27.9±4.5)pg/mL(P<0.01);PCNA指数为(75.2±8.5)%和(86.1±4.8)%(P<0.001)。结论:松友饮灌胃给药下调残癌表达IL-1β和PCNA,抑制残癌生长、转移,对肝癌病人有潜在的应用价值。
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| 关 键 词： | 癌 肝细胞 抗肿瘤药 中药 肿瘤转移 |
Experimental research on inhibition effects of Chinese herbal compound Songyou Yin on tumor growth and metastasis of residual hepatocellular carcinoma following palliative liver resection |
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| HUANG Xiu-yan,HUANG Zi-li,TANG Zhao-you,ZHENG Qi,ZHOU Jian,YE Sheng-long. Experimental research on inhibition effects of Chinese herbal compound Songyou Yin on tumor growth and metastasis of residual hepatocellular carcinoma following palliative liver resection[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2010, 0(12) |
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| Authors: | HUANG Xiu-yan HUANG Zi-li TANG Zhao-you ZHENG Qi ZHOU Jian YE Sheng-long |
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| Affiliation: | HUANG Xiu-yan1,HUANG Zi-li2,TANG Zhao-you3,ZHENG Qi1,ZHOU Jian3,YE Sheng-long3 (1 The Sixth People's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233,China,2The Central Hospital of Shanghai Xuhui District,Shanghai 200031,3Liver Cancer Institute,Fudan University,Shanghai 200032,China) |
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| Abstract: | |
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| Keywords: | Carcinoma Hepatocellular Antineoplastic drugs(TCD) Chinese medicine Neoplasm metastasis |
| 本文献已被 CNKI 等数据库收录！ |
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