通降和胃方治疗胃食管反流病合并夜间呛咳38例临床观察

目的观察通降和胃方治疗胃食管反流病(GERD)合并夜间呛咳的临床疗效。方法对38例患者采用通降和胃方治疗,观察治疗前后患者临床症状积分、胃镜下食管炎症改善情况,并随访复发率。结果①治疗前后患者临床症状积分、呛咳类呼吸道症状积分、胃食管反流症状积分均有显著差异(P<0.01);②临床症状改善总显效率为86.84%,呛咳类呼吸道症状改善显效率为86.84%,胃食管反流症状改善显效率为78.95%,三类症状改善显效率相比无统计学差异(P>0.05);③治疗后胃镜下食管炎症改善总有效率为73.68%;④停药2个月后呼吸道症状复发率为24.32%,胃食管反流症状复发率为37.83%。结论通降和胃方治疗胃食管反流病合并夜间呛咳,可有效缓解临床症状,减轻食管黏膜炎症,且具有复发率较低的优点。

Clinical Observation of "Tongjiang Hewei Decoction" in Treating 38 Cases of Gastroesophageal Reflux Disease with Nighttime Cough

Objective To observe the clinical effects of "Tongjiang Hewei Decoction" in the treatment of patients with gastroesophageal reflux disease(GERD) with nighttime cough.Method Thirty-eight cases were treated with "Tongjiang Hewei Decoction".The symptomatic scores and endoscopic results and recurrence rate were observed.Results The clinical symptomatic scores were obviously decreased after treatment(P < 0.01) ;the effective rate for symptom improvement was 86.64%,the effective rate for nighttime cough improvement was 86.84%,the effective rate for reflux improvement was 78.95%.There was no statistical difference between the three(P > 0.05) .The endoscopic results showed that the effective rate was 73.68%.The recurrence rate of nighttime cough was 24.32%,it was 37.83% for gastroesophageal reflux.Conclusion "Tongjiang Hewei Decoction" can relieve GERD with nighttime cough,improve clinical symptoms effectively,reduce the inflammation of esophageal mucosa and decrease recurrence rate.