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疏肝健脾养心安神法治疗糖尿病抑郁障碍临床研究
引用本文:李红,徐蓉娟,陈建杨,葛芳芳.疏肝健脾养心安神法治疗糖尿病抑郁障碍临床研究[J].上海中医药杂志,2009,43(4):17-19.
作者姓名:李红  徐蓉娟  陈建杨  葛芳芳
作者单位:上海中医药大学附属龙华医院内分泌科,上海,200032  
摘    要:目的观察糖郁汤治疗肝郁脾虚、心神不宁型糖尿病抑郁障碍的临床疗效。方法选择108例患者,共93例纳入分析。均维持原糖尿病基础及降糖药物治疗,随机分为试验组(糖郁汤,n=31)、对照组(左洛复,n=32)和空白组(n=30),疗程12周。观察各组治疗前后中医证候、汉密尔顿抑郁量表、汉密尔顿焦虑量表、糖尿病患者生存质量特异性量表、抗抑郁药副反应评定量表积分及血糖等变化。结果试验组中医证候疗效优于对照组(P〈0.05);试验组与对照组抗抑郁疗效优于空白组(P〈0.01),而两组间差异无统计学意义(P〉0.05);对照组生存质量量表中心理健康积分高于试验组(P〈0.05),其余4项差异均无统计学意义(P〉0.05);试验组仅1例出现不良反应,对照组9例出现不良反应。结论糖郁汤可有效改善肝郁脾虚、心神不宁型糖尿病抑郁障碍患者临床症状,改善糖尿病抑郁及焦虑的不良情绪,有效提高糖尿病抑郁障碍患者生存质量;且具有良好的安全性。

关 键 词:糖尿病抑郁障碍  疏肝健脾  养心安神  糖郁汤  左洛复  汉密尔顿抑郁量表  汉密尔顿焦虑量表  生存质量

Clinical Study on Liver-Coursing,Spleen-Strengthening,Heart-Nourishing and Mind-Calming Therapy for Diabetic Depression
LI Hong XU Rong-juan CHEN Jian-yang GE Fang-fang Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine.Clinical Study on Liver-Coursing,Spleen-Strengthening,Heart-Nourishing and Mind-Calming Therapy for Diabetic Depression[J].Shanghai Journal of Traditional Chinese Medicine,2009,43(4):17-19.
Authors:LI Hong XU Rong-juan CHEN Jian-yang GE Fang-fang Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Institution:( Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine)
Abstract:Objective To observe the clinical efficacy of "Tangyu Decoction" in treating diabetic depression of liver-stagnation and spleen-deficiency syndrome. Methods Ninety cases out of 108 patients were enrolled,and were randomized into treatment group,control group,and blank group. All of the patients were given basic treatment of diabetes and sugar-reducing medicine,and the patients in the treatment group and the control group were treated with "Tangyu Decoction" and Zoloft respectively. The scores of TCM syndrom...
Keywords:Diabetic depression  coursing liver and strengthening spleen  nourishing heart to calm mind  "Tangyu Decocion"  Zoloft  Hamilton depression scale  Hamilton anxiety scale  life quality  
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