| 野葛藤总黄酮提取的工业化生产和实验室工艺验证比较 |
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| 引用本文： | 巩海涛,李宏建,王雁群,刘田云,刘逢芹,李贵海.野葛藤总黄酮提取的工业化生产和实验室工艺验证比较[J].上海中医药杂志,2009,43(5):76-79. |
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| 作者姓名： | 巩海涛 李宏建 王雁群 刘田云 刘逢芹 李贵海 |
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| 作者单位： | 巩海涛,GONG Hai-tao(山东大学药学院,山东,济南,250012;山东药品食品职业学院,山东,威海,264210);李宏建,刘逢芹,LI Hong-jian,LIU Feng-qin(山东大学药学院,山东,济南,250012;山东大学附属千佛山医院,山东,济南,250014);王雁群,WANG Yan-qun(山东药品食品职业学院,山东,威海,264210);刘田云,LIU Tian-yun(山东大学附属千佛山医院,山东,济南,250014);李贵海,LI Gui-hai(山东省中医药研究院,山东,济南,250014)
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| 基金项目： | 国家中医药管理局科研项目，山东省科委攻关计划项目 |
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| 摘 要： | 目的验证比较生产车间和实验室制备的葛藤提取物的内在质量,探讨实验制备与工业化生产工艺之间的差异。方法采用紫外-可见分光光度法和HPLC法,以葛根素、大豆苷、大豆苷元等成分的含量为评价指标,测定葛藤提取物含量,通过HPLC法制作的葛藤提取物指纹图谱比较和分析各提取物中异黄酮成分组成和含量。结果工业化生产和实验室制备的不同批次间葛藤提取物样品的异黄酮含量相近,差异较小,质量稳定。结论葛藤提取物实验室制备工艺转化为产业化工艺流程可靠可行,为工业化生产提供了保障。
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| 关 键 词： | 葛藤提取物 HPLC 葛根素 大豆苷 大豆苷元 指纹图谱 |
Comparison of Flavonoid Extract from Stem of Wild Pueraria Lobata Between Industrial and Laboratory Processes |
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| GONG Hai-tao, LI Hong-jian, WANG Yan-qun LIU Tian-yun LIU Feng-qin, LI Gui-hai.School of Pharmaceutical Sciences,Sh,ong University.Sh,ong Vocational College of Drug , Food.Comparison of Flavonoid Extract from Stem of Wild Pueraria Lobata Between Industrial and Laboratory Processes[J].Shanghai Journal of Traditional Chinese Medicine,2009,43(5):76-79. |
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| Authors: | GONG Hai-tao LI Hong-jian WANG Yan-qun LIU Tian-yun LIU Feng-qin LI Gui-haiSchool of Pharmaceutical Sciences Sh ong UniversitySh ong Vocational College of Drug Food |
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| Institution: | GONG Hai-tao1,2 LI Hong-jian1,3 WANG Yan-qun2 LIU Tian-yun3 LIU Feng-qin1,3 LI Gui-hai41.School of Pharmaceutical Sciences,Sh,ong University2.Sh,ong Vocational College of Drug , Food3.Qianfoshan Hospital Affiliated to Sh,ong University4.Sh,ong Research Institute of Traditional Chinese Medicine |
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| Abstract: | Objective To verify the inherent quality of extracts of the stem of Pueraria lobata that were prepared in industrial production and laboratory,and compare its difference.Methods The contents of the extract of the stem of Pueraria lobata were measured by UV-VIS spectrophotometry and HPLC in terms of Puerarine,Daidzin and Daidzein;the components and contents of Isoflavonids of the extract were analyzed by the fingerprint.Results The mass discrepancy between different batches of commercial process of extract o... |
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| Keywords: | HPLC |
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