| 益气养阴方对非小细胞肺癌术后放疗患者放射性肺炎及肺功能影响的临床研究 |
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| 引用本文： | 姚逸临,李和根,陈智伟,郭金栋,徐蔚杰,周蕾,朱丽华,刘吟絮.益气养阴方对非小细胞肺癌术后放疗患者放射性肺炎及肺功能影响的临床研究[J].上海中医药杂志,2019,53(3):42-46. |
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| 作者姓名： | 姚逸临 李和根 陈智伟 郭金栋 徐蔚杰 周蕾 朱丽华 刘吟絮 |
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| 作者单位： | 上海中医药大学附属龙华医院肿瘤科;上海市胸科医院肿瘤科;上海市胸科医院放疗科 |
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| 基金项目： | 上海市卫计委科研课题计划(面上)项目(201440415)；上海市科委科研计划项目(15401931200) |
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| 摘 要： | 目的观察益气养阴方对非小细胞肺癌(Ⅲa期)术后放疗患者放射性肺炎及肺功能的影响。方法将60例非小细胞肺癌(Ⅲa期)术后放疗患者随机分为治疗组与对照组,每组30例。对照组予术后常规放疗,治疗组在术后常规放疗的同时加服益气养阴方。两组疗程均为28天,观察急性放射性肺炎分级(RTOG分级)和肺功能的变化情况。结果①试验期间,治疗组脱落1例,对照组脱落3例;最终完成试验者56例,治疗组29例,对照组27例。②放疗后2个月与放疗结束时组内比较,治疗组RTOG分级差异有统计学意义(P0.05),对照组RTOG分级差异无统计学意义(P0.05)。组间放疗结束时比较,RTOG分级差异尚无统计学意义(P0.05),治疗组(72.41%)与对照组(85.19%)RP发生率差异无统计学意义(P0.05)。组间放疗后2个月比较,RTOG分级差异有统计学意义,治疗组(37.93%)RP发生率明显低于对照组(85.19%)、炎症程度明显轻于对照组(P0.05)。③放疗结束时与放疗前组内比较,两组FVC、FEV_1、MVV差异均无统计学意义(P0.05);放疗后2个月与放疗前组内比较,对照组FVC、FEV_1、MVV差异有统计学意义,明显降低(P0.05),治疗组FVC、FEV_1、MVV差异无统计学意义,保持稳定(P0.05)。组间放疗结束时比较,FVC、FEV_1、MVV差异无统计学意义(P0.05)。组间放疗后2个月比较,FVC、FEV_1、MVV差异有统计学意义,治疗组明显高于对照组(P0.05)。④重复测量资料的方差分析显示,FVC、FEV_1、MVV组内变异中的时间因素及时间×组别因素存在显著统计学意义(P0.05);组间变异中的组别因素不存在显著统计学意义(P0.05)。结论益气养阴方能在一定程度上稳定Ⅲa期非小细胞肺癌术后放疗患者的肺功能,减少放射性肺炎的发生,并有利于降低其发生后的炎症程度。
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| 关 键 词： | 放射性肺炎 肺功能 非小细胞肺癌 益气养阴方 |
| 收稿时间： | 2018/9/8 0:00:00 |
Clinical study on effects of Yiqi Yangyin Formula on radiation pneumonitis and lung function in patients undergoing postoperative radiotherapy for non-small cell lung cancer |
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| YAO Yilin,LI Hegen,CHEN Zhiwei,GUO Jindong,XU Weijie,ZHOU Lei,ZHU Lihua and LIU Yinxu.Clinical study on effects of Yiqi Yangyin Formula on radiation pneumonitis and lung function in patients undergoing postoperative radiotherapy for non-small cell lung cancer[J].Shanghai Journal of Traditional Chinese Medicine,2019,53(3):42-46. |
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| Authors: | YAO Yilin LI Hegen CHEN Zhiwei GUO Jindong XU Weijie ZHOU Lei ZHU Lihua and LIU Yinxu |
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| Institution: | Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China,Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China,Department of Oncology, Shanghai Chest Hospital, Shanghai 200030, China,Department of Radiotherapy, Shanghai Chest Hospital, Shanghai 200030, China,Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China,Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China,Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China and Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
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| Abstract: | |
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| Keywords: | radiation pneumonitis lung function non-small cell lung cancer Yiqi Yangyin Formula |
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