慢性肾炎中医证型与免疫学指标的相关性分析

目的探讨慢性肾炎中医证型与T淋巴细胞亚群、免疫球蛋白及补体的相关性,为慢性肾炎中医辨证提供客观依据。方法选取120例慢性肾炎患者为评价对象(慢性肾炎组),并选择40例健康人为对照组,同步检测两组的T淋巴细胞亚群、免疫球蛋白及补体,并按照中医证型进行相关性分析。结果与健康组比较,慢性肾炎组患者血Ig A、Ig G、C3、CD3+、CD4+、CD4+/CD8+水平降低,CD8+水平增高(P<0.05,P<0.01);其中,慢性肾炎患者的Ig A、Ig G、CD3+、CD4+、CD4+/CD8+水平在脾肾阳虚型中最低、脾肾气虚型次之、肝肾阴虚型最高,C3在肺肾气虚型中最低,CD8+水平在肝肾阴虚型中最低、脾肾阳虚型中最高,差异均有统计学意义(P<0.05,P<0.01)。结论 T淋巴细胞亚群、免疫球蛋白及补体水平等免疫学客观指标与慢性肾炎有关,且与中医证型存在明显的相关性,提示慢性肾炎阴阳失衡中存在免疫功能缺陷。

Correlation between TCM patterns of chronic glomerulonephritis and immunological parameters

  Objective: To discuss the correlation between TCM patterns of chronic glomerulonephritis and immunological parameters including T-lymphocyte subsets, immunoglobulin and complement, and to provide an   Objective: basis for TCM differentiation of chronic glomerulonephritis  Methods: One hundred and twenty cases with chronic nephritis as the evaluation objects, with 40 cases of healthy people as the control group. T lymphocyte subsets, immunoglobulin and complement were detected, and correlation between the two groups according to TCM patterns was analyzed  Results: Compared with the healthy group, the levels of IgA, IgG, C3, CD3⁺, CD4⁺ and CD4⁺/CD8⁺ were reduced in the chronic glomerulonephritis group, but the CD8⁺ level was increased (P<0.05, P<0.01); IgA, IgG, CD3⁺, CD4⁺ and CD4⁺/CD8⁺ levels of patients with chronic glomerulonephritis is the lowest in the pattern of yang deficiency of spleen and kidney, followed by the pattern of qi deficiency of spleen and kidney, and the highest in the pattern of yin deficiency of liver and kidney. C3 level is the lowest in the pattern of qi deficiency of lung and kidney. CD8⁺ level is the lowest in the pattern of yin deficiency of liver and kidney, and the highest in the pattern of yang deficiency of spleen and kidney. These difference showed statistically significant (P<0.05, P<0.01).Conclusion There has relationship among T lymphocyte subsets, immunoglobulin, complement and chronic glomerulonephritis. There is a clear correlation between TCM patterns and immunological parameters. Our sampl  Results: that patients with chronic nephritis have an imbalance of yin and yang, which may be associate with the immune dysfunction.