| 淫羊藿及其主要成分调节AMPK通路治疗心力衰竭研究进展 |
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| 引用本文： | 李旭,王孟孟,谷飞,高以晴,张博雅,张楚懿,郭茂娟. 淫羊藿及其主要成分调节AMPK通路治疗心力衰竭研究进展[J]. 上海中医药杂志, 2019, 53(1): 106-110 |
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| 作者姓名： | 李旭 王孟孟 谷飞 高以晴 张博雅 张楚懿 郭茂娟 |
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| 作者单位： | 天津中医药大学中西医结合学院,天津,300110,天津中医药大学第一附属医院肾病科,天津,300110,天津中医药大学中西医结合学院,天津,300110,天津中医药大学中西医结合学院,天津,300110,天津中医药大学中西医结合学院,天津,300110,天津中医药大学中西医结合学院,天津,300110,天津中医药大学中西医结合学院,天津,300110 |
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| 基金项目： | 国家自然科学基金项目(81774071)；国家级大学生创新创业基金项目(201710063031)；天津中医药大学院级基金项目(ZXYKY201601) |
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| 摘 要： | 在概述心力衰竭能量代谢特点的基础上,综述淫羊藿及其主要成分调节磷酸腺苷活化蛋白激酶(AMPK)通路治疗心力衰竭研究进展。研究发现,淫羊藿可通过调节AMPK通路的不同靶点治疗心力衰竭:可诱导过氧化物酶体增殖活化受体γ辅助活化因子1α(PGC-1α)的表达激活AMPK,促进能量产生;可调节葡萄糖转运体4(GLUT4)的生成和乙酰辅酶A羧化酶(ACC)表达,优化底物代谢,促进能量生成;可诱导过氧化物酶体增殖物激活受体α(PPARα)表达激活AMPK通路,调节能量生成;可抑制活性氧簇(ROS)产生,增加腺苷三磷酸(ATP)酶活性,提高能量利用。
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| 关 键 词： | 淫羊藿 心力衰竭 AMPK 能量代谢 综述 |
| 收稿时间： | 2018-05-23 |
Research progress of Herba Epimedii and its main components in regulating AMPK pathway in prevention and treatment of heart failure |
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| LI Xu,WANG Mengmeng,GU Fei,GAO Yiqing,ZHANG Boy,ZHANG Chuyi and GUO Maojuan. Research progress of Herba Epimedii and its main components in regulating AMPK pathway in prevention and treatment of heart failure[J]. Shanghai Journal of Traditional Chinese Medicine, 2019, 53(1): 106-110 |
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| Authors: | LI Xu WANG Mengmeng GU Fei GAO Yiqing ZHANG Boy ZHANG Chuyi GUO Maojuan |
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| Affiliation: | College of Integrated Chinese and Western Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300110,China,Department of Nephrology,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300110,China,College of Integrated Chinese and Western Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300110,China,College of Integrated Chinese and Western Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300110,China,College of Integrated Chinese and Western Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300110,China,College of Integrated Chinese and Western Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300110,China and College of Integrated Chinese and Western Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300110,China |
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| Abstract: | |
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| Keywords: | Herba Epimedii heart failure AMPK energy metabolism review |
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