金匮肾气丸对2型糖尿病肾病大鼠IGF-1及ET的影响

目的探讨金匮肾气丸对2型糖尿病。肾病大鼠胰岛素样生长因子-1（insulin-likegrowthfactor-1，IGF-1）及血浆内皮素（endo-thelin，ET）的影响。方法抽取8只大鼠为空白组，其余均制备糖尿病肾病模型。选择造模成功的大鼠40只，随机分为模型组、罗格列酮组、金匮肾气大、中、小剂量组；各组给予相应干预措施共5周，检测空腹血糖（FBG）、尿白蛋白排泄率（UAER）、IGF-1及ET。结果各组给药后FBG较给药前明显降低，差异有统计学意义（P〈0．05，P〈0．01）；各药物组FBG较模型组明显降低，差异有统计学意义（P〈0．05，P〈0．01）；金匮肾气大剂量组与罗格列酮组血糖降低程度相当（P〉0．05），金匮肾气中、小剂量组较金匮肾气大剂量组与罗格列酮组血糖差异有统计学意义（P〈0．01）。与模型组比较，各药物组UAER降低，差异有统计学意义（P〈0．05，P〈0．01）；IGF-1升高，ET降低，差异有统计学意义（P〈0．01）。金匮。肾气各剂量组与罗格列酮组比较，IGF-l差异无统计学意义，ET除金匮肾气小剂量组外（P〈0．05），金匮肾气大、中剂量组差异无统计学意义（P〉0．05）。与金匮肾气大剂量组比较，中、小剂量组UAER差异有统计学意义（P〈0．05，P〈0．01）；与金匮肾气小剂量组比较，大、中剂量组ET差异有统计学意义（P〈0．01）。结论金匮肾气丸叮以降低2型糖尿病。肾病大鼠FBG、UAER、ET，升高IGF-1，从而起到防治糖尿病肾病的作用。

Effects of "Jinkui Shenqi Pill" on insulin-like growth factor-Ⅰ and endothelin in rats of type 2 diabetic nephropathy

Objective To observe the effects of Jinkui Shenqi Pill on IGF-1 and ET in rats of type 2 diabetic nephropathy.Methods Eight rats were selected randomly in blank group.Another 40 rats were created into the diabetic nephropathy rats,and then divided into five groups: model group,rosiglitazone group,Jinkui shenqi groups(large,medium and small dose).Each group was treated for five weeks.The fasting blood glucose(FBG),urinary albumin excretion rate(UAER),IGF-1 and ET were detected.Results The levels of FBG was d...