| 温振运气方对慢性疲劳综合征患者负性情绪及脑海马区功能代谢影响的临床研究 |
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| 引用本文： | 黄瑶,张振贤,陈若宏,吴丽丽,陈敏. 温振运气方对慢性疲劳综合征患者负性情绪及脑海马区功能代谢影响的临床研究[J]. 上海中医药杂志, 2016, 50(10): 60-63 |
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| 作者姓名： | 黄瑶 张振贤 陈若宏 吴丽丽 陈敏 |
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| 作者单位： | 上海中医药大学附属岳阳中西医结合医院中医内科,上海,200437,上海中医药大学附属岳阳中西医结合医院中医内科,上海,200437,上海中医药大学附属岳阳中西医结合医院中医内科,上海,200437,上海中医药大学附属岳阳中西医结合医院中医内科,上海,200437,上海中医药大学附属岳阳中西医结合医院中医内科,上海,200437 |
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| 基金项目： | 国家自然科学基金资助项目(81373624)；国家中医药管理局“十二五”中医药重点学科建设“治未病”项目(2011-2015)；上海中医药大学附属岳阳中西医结合医院慢疲重点专病项目 |
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| 摘 要： | 目的观察温振运气方治疗慢性疲劳综合征伴负性情绪的临床疗效。方法将153例受试者随机分为健康组(50例)、治疗组(51例)及对照组(52例)。健康组不予干预,治疗组予温振运气方,对照组予中成药逍遥丸。两组疗程均为3个月,观察疲劳量表(F-14)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)及健康状况调查问卷(SF-36)积分的变化情况,以及双侧海马区氢质子磁共振波谱(1H-MRS)调节作用的强弱。结果 1试验期间,脱落3例(治疗组1例、对照组2例);最终完成试验者150例,每组50例。2治疗前后组内比较,两组F-14、HAMD、HAMA积分差异均有统计学意义(P0.05);组间治疗后比较,F-14、HAMD、HAMA积分差异有统计学意义,治疗组改善疲劳及负性情绪作用明显优于对照组(P0.05)。3治疗前后组内比较,治疗组SF-36在躯体功能、总体健康、生命活力、情感职能、心理健康五个维度积分上差异有统计学意义(P0.05),对照组在生命活力、心理健康两个维度积分上差异均有统计学意义(P0.05)。组间治疗后比较,SF-36在躯体功能、总体健康、生命活力、情感职能、心理健康五个维度积分上差异有统计学意义(P0.05)。4治疗前健康组与治疗组、对照组左侧、右侧海马区NAA/Cr、Cho/Cr比值差异均有统计学意义(P0.05),而治疗组与对照组NAA/Cr、Cho/Cr比值差异无统计学意义(P0.05)。治疗前后组内比较,治疗组左侧、右侧海马NAA/Cr比值显著升高,左侧海马Cho/Cr比值显著降低(P0.05),右侧海马Cho/Cr比值差异无统计学意义(P0.05);对照组双侧海马NAA/Cr、Cho/Cr比值差异无统计学意义(P0.05)。组间治疗后比较,治疗组较对照组的左侧、右侧海马NAA/Cr比值升高更多,左侧海马Cho/Cr比值降低更多(P0.05)。结论温振运气方治疗慢性疲劳综合征,能较明显改善患者的负性情绪及躯体疲劳,提高患者生存质量,其作用机制可能与调节中枢脑海马区功能代谢(NAA/Cr、Cho/Cr)有关。
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| 关 键 词： | 慢性疲劳综合征 负性情绪 温振运气方 中枢作用机制 海马区 |
| 收稿时间： | 2016-05-16 |
Clinical effect of Wenzhen Yunqi Recipe on the negative emotion and hippocampus functional metabolism in patients with chronic fatigue syndrome |
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| HUANG Yao,ZHANG Zhen-xian,CHEN Ruo-Hong,WU Li-li and CHEN Min. Clinical effect of Wenzhen Yunqi Recipe on the negative emotion and hippocampus functional metabolism in patients with chronic fatigue syndrome[J]. Shanghai Journal of Traditional Chinese Medicine, 2016, 50(10): 60-63 |
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| Authors: | HUANG Yao ZHANG Zhen-xian CHEN Ruo-Hong WU Li-li CHEN Min |
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| Affiliation: | Department of Chinese Medicine,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200437,Department of Chinese Medicine,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200437,Department of Chinese Medicine,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200437,Department of Chinese Medicine,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 and Department of Chinese Medicine,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 |
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