| 镇惊泻火颗粒治疗痰热内扰型轻中度焦虑症的随机、双盲、安慰剂对照研究 |
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| 引用本文： | 叶青,袁晓蕾,周洁,袁灿兴.镇惊泻火颗粒治疗痰热内扰型轻中度焦虑症的随机、双盲、安慰剂对照研究[J].上海中医药杂志,2016,50(12):37-40. |
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| 作者姓名： | 叶青 袁晓蕾 周洁 袁灿兴 |
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| 作者单位： | 上海中医药大学附属龙华医院脑病科,上海,200032,上海中医药大学附属龙华医院脑病科,上海,200032,上海中医药大学附属龙华医院脑病科,上海,200032,上海中医药大学附属龙华医院脑病科,上海,200032 |
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| 基金项目： | 上海市科委科研计划项目(13401901701)；国家自然科学基金面上项目(81673726)；上海市卫计委杏林新星人才计划项目(ZY3-RCPY-2-2005) |
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| 摘 要： | 目的观察镇惊泻火颗粒治疗痰热内扰型轻中度焦虑症的临床疗效。方法将100例痰热内扰型轻中度焦虑症患者随机分为治疗组与对照组,每组50例。治疗组予镇惊泻火颗粒,对照组予安慰剂颗粒。两组疗程均为2个月,观察Hamilton焦虑量表(HAMA)评分、焦虑自评量表(SAS)评分、匹茨堡睡眠质量指数量表(PSQI)评分、中医证候积分的情况及用药安全性。结果 1试验中共脱落7例,最终有93例患者完成试验,其中治疗组为48例,对照组为45例。2组间治疗后比较,HAMA及SAS评分差异有统计学意义,治疗组比对照组进一步降低(P0.05)。3治疗前后组内比较,两组PSQI评分差异均有统计学意义,均显著降低(P0.05);组间治疗前后PSQI评分差值比较,差异有统计学意义,治疗组比对照组进一步降低(P0.05)。4治疗前后组内比较,两组中医证候积分差异均有统计学意义,均显著降低(P0.05);组间治疗前后中医证候积分差值比较,差异有统计学意义,治疗组比对照组进一步降低(P0.05)。5组间不良反应发生率比较,差异无统计学意义(P0.05)。结论镇惊泻火颗粒治疗痰热内扰型轻中度焦虑症的疗效满意,可有效降低患者焦虑程度,改善睡眠质量。
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| 关 键 词： | 广泛性焦虑症 痰热内扰 镇惊泻火 随机双盲平行对照 安慰剂 |
| 收稿时间： | 2016/7/8 0:00:00 |
Efficacy of Zhenjing Xiehuo Granule on mild-to-moderate anxiety with internal disturbance of phlegm-heat:a randomized, double-blind, placebo controlled trial |
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| YE Qing,YUAN Xiao-lei,ZHOU Jie and YUAN Can-xing.Efficacy of Zhenjing Xiehuo Granule on mild-to-moderate anxiety with internal disturbance of phlegm-heat:a randomized, double-blind, placebo controlled trial[J].Shanghai Journal of Traditional Chinese Medicine,2016,50(12):37-40. |
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| Authors: | YE Qing YUAN Xiao-lei ZHOU Jie and YUAN Can-xing |
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| Institution: | Department of Neurology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200032,Department of Neurology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200032,Department of Neurology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200032 and Department of Neurology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200032 |
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| Abstract: | |
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| Keywords: | generalized anxiety disorder internal disturbance of phlegm-heat Zhenjing Xiehuo randomized double-blind parallel controlled trial placebo |
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