| 胃康宁治疗脾虚寒热瘀毒型慢性萎缩性胃炎伴胃癌前病变临床疗效及调节COX-2蛋白的机制研究 |
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| 引用本文： | 刘涛,张霞,魏玮.胃康宁治疗脾虚寒热瘀毒型慢性萎缩性胃炎伴胃癌前病变临床疗效及调节COX-2蛋白的机制研究[J].上海中医药杂志,2016,50(11):46-48, 68. |
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| 作者姓名： | 刘涛 张霞 魏玮 |
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| 作者单位： | 中国中医科学院望京医院脾胃病科,北京,100102,大同大学医学院中医系,山西大同,037000,中国中医科学院望京医院脾胃病科,北京,100102 |
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| 基金项目： | 北京市科委G20工程支撑保障项目(Z16110000 1816016) |
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| 摘 要： | 目的 观察胃康宁治疗脾虚寒热瘀毒型慢性萎缩性胃炎伴胃癌前病变患者的临床疗效及调节COX-2蛋白的机制。方法将90例脾虚寒热瘀毒型慢性萎缩性胃炎伴胃癌前病变患者随机分为治疗组和对照组,每组45例。治疗组口服胃康宁组方,对照组口服胃复春片,疗程均为12周。观察临床疗效、病理改变,比较两组中医证候积分和胃黏膜COX-2蛋白变化情况。结果 1治疗组、对照组临床总有效率分别为93.3%和57.6%;组间临床疗效比较,差异有统计学意义(P0.05)。2治疗前后组内比较,两组炎症、萎缩、肠化生积分和总积分差异均有统计学意义(P0.05)。组间治疗后比较,两组炎症、萎缩、肠化生积分和总积分差异均有统计学意义(P0.05)。3治疗前后组内比较,胃痛、痞满、嘈杂、乏力、纳呆积分和总积分差异均有统计学意义(P0.05)。组间治疗后比较,胃痛、痞满、纳呆积分和总积分差异均有统计学意义(P0.05)。4治疗前后组内比较,治疗组COX-2值差异有统计学意义(P0.05);组间治疗后比较,COX-2值差异有统计学意义(P0.05)。结论 胃康宁治疗脾虚寒热瘀毒型慢性萎缩性胃炎伴胃癌前病变临床疗效满意,可显著改善患者临床症状,缓解胃黏膜炎症,逆转胃黏膜萎缩和肠上皮化生,降低胃黏膜COX-2蛋白表达可能为机制之一。
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| 关 键 词： | 胃康宁 辛开苦降法 慢性萎缩性胃炎 胃癌前病变 临床疗效 机制研究 |
| 收稿时间： | 2016/6/19 0:00:00 |
Research on the clinical efficacy of Weikangning in the treatment of chronic atrophic gastritis with precancerous lesions of spleen deficiency and cool-heat stagnation pattern and regulation mechanism on COX-2 protein |
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| LIU Tao,ZHANG Xia and WEI Wei.Research on the clinical efficacy of Weikangning in the treatment of chronic atrophic gastritis with precancerous lesions of spleen deficiency and cool-heat stagnation pattern and regulation mechanism on COX-2 protein[J].Shanghai Journal of Traditional Chinese Medicine,2016,50(11):46-48, 68. |
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| Authors: | LIU Tao ZHANG Xia and WEI Wei |
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| Institution: | Department of Spleen and Stomach Diseases,Wangjing Hospital,China Academy of Chinese Medicine Sciences,Beijing,100102,Department of Traditional Chinese Medicine,Medical College of Datong University,Shanxi,037000 and Department of Spleen and Stomach Diseases,Wangjing Hospital,China Academy of Chinese Medicine Sciences,Beijing,100102 |
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