| lncRNA作为竞争性内源RNA调控肝癌及中药作用机制研究进展 |
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| 引用本文： | 史苗娟,郭鑫昕,商嘉玮,苏式兵,张辉.lncRNA作为竞争性内源RNA调控肝癌及中药作用机制研究进展[J].上海中医药杂志,2017,51(11):91-96. |
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| 作者姓名： | 史苗娟 郭鑫昕 商嘉玮 苏式兵 张辉 |
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| 作者单位： | 上海中医药大学交叉科学研究院中医复杂系统研究中心,上海,201203,上海中医药大学交叉科学研究院中医复杂系统研究中心,上海,201203,上海中医药大学交叉科学研究院中医复杂系统研究中心,上海,201203,上海中医药大学交叉科学研究院中医复杂系统研究中心,上海,201203,上海中医药大学交叉科学研究院中医复杂系统研究中心,上海,201203 |
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| 基金项目： | 国家自然科学基金项目(81373518,81773979) |
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| 摘 要： | 针对lncRNA作为ceRNA与miRNA(lncRNA/miRNA/mRNA)相互作用调控肝癌的进展进行综述,包括lncRNA/miRNA/mRNA在肝癌发生发展进程中的功能、机制,lncRNA/miRNA/mRNA调控通路与中药作用机制研究。lncRNA/miRNA/mRNA丰富了肝癌的发生、发展机制,为肝癌诊断及治疗提供新思路。
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| 关 键 词： | lncRNA ceRNA miRNA 肝癌 中药机制 综述 |
| 收稿时间： | 2017/4/15 0:00:00 |
Review of lncRNA acting as competitive endogenous RNA in hepatocellular carcinoma regulation and mechanism research of Chinese medicine |
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| SHI Miao-juan,GUO Xin-xin,SHANG Jia-wei,SU Shi-bing and ZHANG Hui.Review of lncRNA acting as competitive endogenous RNA in hepatocellular carcinoma regulation and mechanism research of Chinese medicine[J].Shanghai Journal of Traditional Chinese Medicine,2017,51(11):91-96. |
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| Authors: | SHI Miao-juan GUO Xin-xin SHANG Jia-wei SU Shi-bing and ZHANG Hui |
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| Institution: | Research Center for Traditional Chinese Medicine Complexity System, Research Institute of Disciplinary Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203,Research Center for Traditional Chinese Medicine Complexity System, Research Institute of Disciplinary Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203,Research Center for Traditional Chinese Medicine Complexity System, Research Institute of Disciplinary Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203,Research Center for Traditional Chinese Medicine Complexity System, Research Institute of Disciplinary Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 and Research Center for Traditional Chinese Medicine Complexity System, Research Institute of Disciplinary Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 |
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| Abstract: | Long noncoding RNA (lncRNA),as competitive endogenous RNA (ceRNA),can interact with miRNA(lncRNA/miRNA/mRNA)and play the role in the regulation of hepatocellular carcinoma. This paper reviews the functions and mechanisms of lncRNA/miRNA/mRNA in the occurrence and development of hepatocellular carcinoma,and researches about lncRNA/miRNA/mRNA regulation pathway and Chinese medicine mechanism. lncRNA/miRNA/mRNA enrich the occurrence and development mechanism of hepatocellular carcinoma,and provide novel insight into the diagnosis and therapy of hepatocellular carcinoma. |
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