基于因子分析和聚类分析的140例首发精神分裂症中医证候规律研究

目的探讨首发精神分裂症中医证候特征和分型规律,为该病中医证候客观化及辨治提供参考依据。方法制定精神分裂症中医证候观察表,通过标准化四诊信息采集,共纳入首发精神分裂症患者140例;建立数据库,采用因子分析和聚类分析等多元数理统计学方法,进行中医证候研究。结果中医证候研究共得到22个公因子,合并为5个最为符合临床的因子证候组合,按解释的总方差由高到低依次为气血凝滞(47.86%)、气虚痰结(20.00%)、肝郁脾虚(18.57%)、痰火扰心(5.71%)、阳明热盛(5.71%)。结论气滞、血瘀和痰结为临床首发精神分裂症的主要证候要素。

Study on Chinese medical syndrome rules of first-episode schizophrenia:A report of 140 cases based on factor analysis and cluster analysis

  Objective:To discuss the Chinese medical syndrome characteristics of first-episode schizophrenia and rules of patterns classification,and provide reference for the objectification of Chinese medical syndrome and differentiation and treatment of this disease. MethodsThe observation table of Chinese medical syndrome on first-episode schizophrenia was formulated. By the standardized collection of four diagnostic information,a total of 140 patients with first-episode schizophrenia were included. The database was established,and the study of Chinese medical syndrome was performed by multivariate mathematical statistics such as factor analysis and cluster analysis.  Results:Totally 22 common factors were obtained in the study of Chinese medical syndrome,which merged into 5 combinations of syndrome factors that most consistent with the clinic. According to the descending order,the syndrome of stagnation of qi and blood could account for 47.86% of the total variation,followed by the syndrome of qi deficiency and phlegm accumulation(account for 20.00%),the syndrome of liver-qi stagnation and spleen deficiency(account for 18.57%),the syndrome of phlegm-fire disturbing heart(account for 5.71%)and the syndrome of intense heat of Yang Ming(account for 5.71%)in turn.  Conclusion:Qi stagnation,blood stasis and phlegm accumulation are the major syndrome elements of first-episode schizophrenia in clinic.