肝郁证与神经内分泌网络和血管舒缩平衡紊乱的相关性实验研究 |
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引用本文: | 刘建鸿,姚凝,王昕,王淳.肝郁证与神经内分泌网络和血管舒缩平衡紊乱的相关性实验研究[J].中国中医基础医学杂志,2010(3). |
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作者姓名: | 刘建鸿 姚凝 王昕 王淳 |
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作者单位: | 甘肃中医学院;西安交通大学医学院;北京中医药大学; |
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基金项目: | 甘肃省教育厅资助项目(024-06) |
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摘 要: | 目的:探讨肝郁证与神经内分泌网络中大鼠下丘脑-腺垂体-肾上腺皮质轴(HPA)的关系和血管舒缩平衡紊乱的相关性。方法:采用"颈部带枷单笼喂养法"复制大鼠肝郁证模型。用放射免疫法检测模型2周组、4周组下丘脑促肾上腺皮质激素释放激素(CRH)、血浆促肾上腺皮质激素(ACTH)、皮质酮(CORT)、血浆内皮素(ET)含量,用比色法检测血清一氧化氮(NO)含量以及丙氨酸氨基转移酶(ALT)活性。结果:实验显示应激大鼠呈现急性应激躁狂,2周和4周应激大鼠呈现慢性应激肝郁证时的抑郁状态;肝郁证模型大鼠下丘脑CRH、血浆ACTH、CORT和ET浓度较正常对照组显著升高,血清NO含量降低;而且肝脏组织有明显损伤,血清ALT活性增加。结论:肝郁证与HPA轴有相关性,并且出现血管舒缩功能的紊乱,肝脏细胞的损伤。
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关 键 词: | 肝郁证 下丘脑-腺垂体-肾上腺皮质轴 内皮素 一氧化氮 丙氨酸氨基转移酶 |
Experimental Study on Correlations of Liver Stagnation Syndrome,Neuroendocrine Network and Vasomotion Disorder |
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Abstract: | Objective:The relation with stagnation of liver and hypothalamic-pituitary-adrenal cortex coaxial and ET,NO,ALT in rats.Methods: The model with stagnation of liver qi was made by separated feeding with neck cangue.Stringently according to operating rule observe hypothalamic CRH the indexes-ACTH,CORT,ET from the rat's blood plasma and NO,ALT from the rat's blood serum in order to study the correlation.Results: stagnation of liver can increase the CRH,ACTH,CORT,ET and ALT,and decrease NO in the stagnation of ... |
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Keywords: | stagnation of liver hypothalamic-pituitary-adrenal cortex coaxial ET NO ALT |
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