| 从血管内皮细胞的分泌功能探讨温病气分证与微观血瘀相关性的实验研究 |
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| 引用本文： | 杨爱东,沈庆法.从血管内皮细胞的分泌功能探讨温病气分证与微观血瘀相关性的实验研究[J].中国中医基础医学杂志,2001,7(2):41-43. |
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| 作者姓名： | 杨爱东 沈庆法 |
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| 作者单位： | 上海中医药大学，上海 200032 |
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| 基金项目： | 上海市教委发展基金资助项目(编号：97基-3) |
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| 摘 要： | 目的：从血管内皮细胞的分泌功能探讨了分证与微观血瘀的相关性。方法：实验采用大肠杆菌内素毒从家兔耳缘静脉注射造成温病气分证模型，观察模型组病理学、血管内皮细胞的分泌功能的改变。结果，模型组光镜下肺脏有微血栓存在，且模型组动物出现t-PA/PAI、NO／ET、TXB2／6酮－PGI1α平衡破坏。结论：温病气分证存在微观血瘀，温病气分证微观血瘀形成机理可能与内皮细胞释放的血管活性物质，如ET／NO、t-PA/PAI、TXB2／6－酮－PGI1α之间的平衡失调有关。
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| 关 键 词： | 温病气分证 内皮素 一氧化氮 组织纤溶酶原激活物 组织纤溶酶原激活物抑制剂 |
| 文章编号： | 1006-3250(2001)02-0041-03 |
| 修稿时间： | 2000年5月11日 |
Experimental Study on
Relativity Between Oifen Syndrome and Microcosmic Blood Stasis from Secrerive Function of
Vaso-endothelial Cells in Seasonal Febrile Disease |
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| YANG Ai dong,SHEN Qing fa.Experimental Study on
Relativity Between Oifen Syndrome and Microcosmic Blood Stasis from Secrerive Function of
Vaso-endothelial Cells in Seasonal Febrile Disease[J].Chinese Journal of Basic Medicine In Traditional Chinese Medicine,2001,7(2):41-43. |
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| Authors: | YANG Ai dong SHEN Qing fa |
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| Abstract: | Objective:To observe the mechanism of relativity between Qifensyndrome and microcosmic blood stasis from secrerive function of vaso-endothelial cells in seasonal febrile disease (SFR).Method:Qifen syndrome in SFR model was induced by colibacillary endotoxin via auricular intravenous injection.The change on pathomorphology,secrerive function of vaso-endothelial cells in seasonal in the model was observel.Result:It showed the existence of microthrombus in the lung via microscope in the model,It also indicated that the balance destruction of t-PA/PAI、HO/ET、TXB2/6-酮-PGI1α.Conclusion:Qifen syndrome in SFR model exist microcosmic blood stasis,The mechanism of microcosmic blood stasis may be related to the balance destruction of t-PA/PAI、NO/ET、TXB2/6-酮-PGI1α which was emitted by endoehelial cells. |
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| Keywords: | Qifen syndrome in seasonal febrile t-PA PAI NO ET TXB2 6-酮-PGI1α |
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