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止喘汤对哮喘大鼠血清IL-13、IgE及肺功能作用的研究
引用本文:陈卓,霍博雅.止喘汤对哮喘大鼠血清IL-13、IgE及肺功能作用的研究[J].中国中医基础医学杂志,2010(5).
作者姓名:陈卓  霍博雅
作者单位:辽宁医学院;辽宁医学院附属第三医院中医科;
基金项目:辽宁省教育厅科研资助项目(2008420)
摘    要:目的:探讨止喘汤对哮喘大鼠血清白细胞介素13(IL-13)、IgE、气道高反应性(Re)及病理变化的作用。方法:30只大鼠分成模型组、正常组、治疗组,经卵蛋白免疫建立模型,止喘汤灌胃4周。经酶联免疫吸附(ELISA)法检测血清IL-13、IgE含量;应用肺功能仪测定Re,光镜下观察病理变化。结果:治疗组大鼠血清IL-13、IgE水平较模型组低(P0.01);模型组Re较高,与正常组、治疗组比较差异均有统计学意义(P0.05);模型组病理变化明显强于正常组、治疗组。结论:止喘汤可降低哮喘大鼠血清IL-13、IgE水平,可改善气道高反应性,值得进一步探讨。

关 键 词:止喘汤  支气管哮喘  白细胞介素13  气道高反应性  

Effects of Zhichuan Decoction on Interleukin-3,IgE and Lung Functions in Asthmatic Rats
CHEN Zhuo,HUI Bo-ya.Effects of Zhichuan Decoction on Interleukin-3,IgE and Lung Functions in Asthmatic Rats[J].Chinese Journal of Basic Medicine In Traditional Chinese Medicine,2010(5).
Authors:CHEN Zhuo  HUI Bo-ya
Institution:CHEN Zhuo1,HUI Bo-ya2(1.Liaoning College of Medicine,No.40 Songpo Road,Jinzhou 121001,China,2.Department of Traditional Chinese Medicine in the Third Affiliated Hospital of Liaoning College of Medicine 121001,China)
Abstract:Objective:To explore the effect of zhichuan decoction on interleukin 13,IgE,responsiveness and pathological change in the serum of asthmatic rat.Methods:Thirty rats were divided into 3 groups:the model group,the control group,the therapeutic group.The asthmatic models of rat were established by immunized with ovalbumin(OVA),zhichuan decoction was given in four weeks.The contents of IL-13,IgE in the serum were measured by ELISA.The mean expiratory resistance(Re)of rats were tested by pulmonary function.Resul...
Keywords:Zhichuan decoction  Bronchus Asthma  Interleukin-13  Airway Responseness  
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