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丹皮酚对高脂血症大鼠动脉内皮细胞的保护作用
引用本文:戴敏,刘青云,訾晓梅.丹皮酚对高脂血症大鼠动脉内皮细胞的保护作用[J].中国中医基础医学杂志,2001,7(2):38-40.
作者姓名:戴敏  刘青云  訾晓梅
作者单位:安徽中医学院,安徽 合肥 230031
摘    要:目的研究丹皮酚(Pae)对高脂血症大鼠动脉内皮细胞的保护作用。方法采用含胆固醇高脂饮食喂养大鼠6周形成高脂血症模型。硝酸还原酶法测定一氧化氮(NO),放射性免疫法检测内皮素(ET),前列环素(PGI

关 键 词:丹皮酚  高脂血症  一氧化氮  内皮素  前列环素  中医药疗法
文章编号:1006-3250(2001)02-0039-03
修稿时间:2000年5月11日

Protective Effective of Paeonol on Artery Endothelial Cells of the Hyperlipidaemia Rats
Abstract:Objective:To study the protective effect of Paeonol(Pae)on arteryendothelial cells of the hyperlipidaemia rats.Methods:The rat model of hyperlipidaemia was established by feeding high lipid diet with cholesterol in rats for 6 weeks.The contents of nitric oxide(NO)was examined with nitric acid reductase method.Radioimmunoassay was used to detect the levels of Endothelin(ET),Prostacyline(PGI2)and Thromboxane A(TXA2).Results:After Pae(300、150mg/kg-1)was taken by oral administration for 6 weeks,NO in serum of the hyperlipiddaemia rats could be elevated distinctly.Pae(150mg.kg-1)could evidently reduce the levels ET in plasm.Pae(300mg.kg-1)could remarkly increase the contents of PGI2.Conclusion:Pae had the effects of increasing NO,PGI2 and decreasing ET,which was of benefit to protect artery endothelial cells function of the hyperlipiddaemia rats and inhibit the formation and development of atherosclerosis
Keywords:Paeonol  hyperlipiddaemia  nitric oxide  endothelin  prostacyline
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