| 基于倾向性评分的中医复杂干预临床疗效评价 |
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| 引用本文： | 叶晓勤,杨伟,谢雁鸣,王永炎.基于倾向性评分的中医复杂干预临床疗效评价[J].中国中医基础医学杂志,2012(2):218-220. |
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| 作者姓名： | 叶晓勤 杨伟 谢雁鸣 王永炎 |
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| 作者单位： | 中国中医科学院中医临床基础医学研究所;中国人民大学统计学院 |
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| 基金项目： | 国家高新技术研究发展计划(863计划)“缺血性中风早期康复和避免复发中医方案研究”(2007AA02Z4B2);中国中医科学院自主选题研究项目“基于倾向性分析的缺血性中风早期康复中医复杂干预疗效评价研究”(Z02108) |
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| 摘 要： | 临床研究的成功与否,与是否有效控制偏倚有关。在非随机化的观察性研究中,倾向性评分能减少对比组间的差异,缩小偏倚。与试验设计阶段进行配比控制偏倚相比,倾向性分析法不受试验设计(随机对照试验设计)方法的限制,无须在试验设计阶段进行随机,其结果更接近"真实世界"的实际干预效果而非临床试验的效果。因此,倾向性分析应用于中医个性化治疗的复杂干预疗效评价是适合的,具有重要的研究前景和使用价值。
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| 关 键 词： | 倾向性分析 混杂因素 中医复杂干预 疗效评价 |
Propensity score-based clinical efficacy evaluation of TCM complex interventions |
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| YE Xiao-qin,YANG Wei,XIE Yan-ming,WANG Yong-yan.Propensity score-based clinical efficacy evaluation of TCM complex interventions[J].Chinese Journal of Basic Medicine In Traditional Chinese Medicine,2012(2):218-220. |
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| Authors: | YE Xiao-qin YANG Wei XIE Yan-ming WANG Yong-yan |
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| Institution: | 1(1.Institute of basic research in clinical trial,China Academy of Chinese Medical Sciences,Beijing 100700,China; 2.School of Statistics,Renmin University of China,Beijing 100872,China) |
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| Abstract: | The success of clinical research,depends on the ability to control the bias.In the non-randomized observational study,propensity score can reduce the contrast differences between groups and narrow bias.Compared with design stage through matching control bias,propehsity analysis frees from experimental design(randomized controlled trial design) approach limits,with no need for rahdomization in the design stage.The result is closer to "real world" aitual effectiveness rather than the clinical trial results.Therefore,propehsity analysis applying to personalized medicine treatment efficacy evaluation of complex interventions is appropriate,has an important prospects and use value. |
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| Keywords: | propensity score analysis Confounding factors TCM complex intervention clinical efficacy evaluation |
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