远志及其不同蜜炙品的急性毒性及其对胃肠运动的影响

目的:考察远志生品与不同蜜炙品(1、2、3、6号)的急性毒性及对小鼠胃肠运动的影响。方法:采用急性毒性LD50法、胃排空甲基橙比色法及小肠炭末推进法,对比远志不同蜜炙品与生品对小鼠全身毒性及胃肠靶器官的毒性。结果:蜜远志1、2、3号的急性毒性均小于生远志(P<0.05,P<0.01);生远志、蜜远志1号、2号、6号8g/kg组与空白组比较,能显著抑制胃排空(P<0.01),而蜜远志3号8g/kg、4g/kg组对胃排空则无明显影响;生远志8g/kg组能显著抑制小肠推进率,且与其余各组比较,均存在显著差异(P<0.05;P<0.01)。结论:蜜远志3号对全身及胃肠运动的毒副反应较小,安全性相对较高。

Effects on acute toxicity and gastrointestinal motility between various Honey-stir-baked and Crude Radix Polygalae

Objective:To inspect the LD_50 and the influence of gastrointestinal motility on mice between Crude and various Honey-stir-baked Radix Polygalae(No.1,2,3,6).Methods and results:Using LD_50 of acute toxicity,methyl orange colorimetry of gastric emptying and charcoal propulsion of small intestine,to research the mice's general and target organ toxicity on stomach and intestines between Crude and Honey-stir-baked Radix Polygalae.The result indicated that,acute toxicity of Honey-stir-baked Radix Polygalae(No.1,2,3)are smaller than that of Crude(P<0.05,P<0.01);Comparing with the control,the 8g/kg group of Crude and Honey-stir-baked Radix Polygalae(No.1,2,6)can remarkably restrain gastric emptying(P<0.01),but the 8g/kg?4g/kg groups of Honey-stir-baked(No 3)have no influence on gastric emptying;The 8g/kg group of Crude Radix Polygalae can remarkably suppress rate of small intestine propulsion,and has the remarkable difference with other each group(P<0.05;P<0.01).Conclusion:The general and gastrointestinal motility toxicity of Honey-stir-baked Radix Polygalae(No.3)are small,and the security comparatively high.