中药骨康对去势大鼠骨吸收与骨形成影响的实验研究

目的：评价中药骨康防治骨质疏松症的作用。方法：60只雌性大鼠随机分正常组，模型组，骨康防治组（高、中、低三个剂量组）及尼尔雌醇防治组，除正常组其余各组均切除卵巢，实验前后检测血清E2、IL-6、BGP、ALP和尿HOP含量，实验结束前检测骨密度。结果：骨康防治组骨密度和血清E2含量高于模型组，血清IL-6及尿HOP含量明显低于模型组。结论：去卵巢引起骨吸收加速，这可能与E2的水平较低及IL-6水平较高有关，骨康可防止去卵巢后的骨吸收，这可能与其提高体内E2含量有关，E2含量的提高，IL-6分泌减少，从而抑制骨吸收。

Experimental Study of Gukang Oral Liquid for Osteoporosis in Ovariecomized Female Rats

Objective:With the aim of studying the therapeutic effect of GOL in ovariectomized female rats,and tried find out the mechanism of GOL in postmenopausal osteoporosis.Methods:Sixty female rats were randomly allocated to six groups:normal group,model group,three GOL groups(with high,moderate and low dosages,respectively)and nilestriol group.All groups were resected ovaries expect normal group.Before and after the experiment,the levels of E 2,IL-6,BGP and ALP in serum were determined,the HOP in urinary were measured too.And BMD was measured before experiment ended.Results:There were no significantly difference of all markers in all groups before experiment.There was significantly difference in BMD,E 2,IL-6 and Urinary HOP between GOLgroups and model group.The BMD and E 2 of GOL groups was higher than that of the model group,meanwhile the IL-6,and Urinary HOP of GOL groups was lower than that of the model group.Conclusion:The results shows that the effect of ovariecttomy cause Bone resorption accelerated.This may be the consequence of decreased expression of E 2 and the increased expression of IL-6.GOL can prevent osteoporosis in overiectomized rats,this may be relation with the increasing of E 2,the increasing of E 2 leads to the expression of IL-6 and Inhibition of Bone resorption.