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骨质疏松症中医证型与细胞因子、性激素、骨钙素的相关性临床研究
引用本文:吴健雄,黄崇博,蔡桦,赵可伟,刘庆思.骨质疏松症中医证型与细胞因子、性激素、骨钙素的相关性临床研究[J].中国中医骨伤科杂志,2008,16(6):1-4.
作者姓名:吴健雄  黄崇博  蔡桦  赵可伟  刘庆思
作者单位:广州越秀区正骨医院,广州,越秀,510030
基金项目:广东省中医药管理局科研项目
摘    要:目的:探讨骨质疏松症中医证型与细胞因子、性激素、骨钙素的相关性。方法:两个医院在3个月内收集80例骨质疏松症患者,辨证分为肾阳虚衰、肝肾阴虚、脾肾阳虚、气滞血瘀四组,抽取血液样本,检测七个指标:雌二醇(E2)、睾酮(T)、白介素-6(IL-6)、肿瘤坏死因子(TNF—α)、胰岛素样生长因子(IGF-1)、骨保护素(OPG)、骨钙素(BGP)。结果:E2在四组证型的气滞血瘀组与肾阳虚衰组之间有统计学意义(P=0.008),IGF-1z在四组证型的肝肾阴虚组与气滞血瘀组之间有统计学意义(P=0.035),余指标的四组证型未见有统计学意义。结论:雌二醇(E2)/胰岛素样生长因子(IGF-1)两个指标可以作为骨质疏松症中医证型虚证(肾阳虚衰或肝肾阴虚)与实证(气滞血瘀)的鉴别诊断指标之一,中医证型存在客观的现代医学指标。

关 键 词:骨质疏松症  细胞因子  性激素  骨钙素  中医证型
文章编号:1005-0205(2008)06-0001-04
修稿时间:2007年11月25

Clinical Study of the Relationships Between Four TCM Syndrome And Cytokines/Hormones/BGP
WU Jianxiong,HUANG Chongbo,CAI Ha,ZHAO Kewei,LIU Qingsi.Clinical Study of the Relationships Between Four TCM Syndrome And Cytokines/Hormones/BGP[J].Chinese Journal of Traditional Medical Traumatology & Orthopeics,2008,16(6):1-4.
Authors:WU Jianxiong  HUANG Chongbo  CAI Ha  ZHAO Kewei  LIU Qingsi
Institution:WU Jianxiong, HUANG Chongbo, CAI Ha ,ZHAO Kewei, LIU Qingsi (Seting Bone Hospital of YueXiu District,Gangzhou 510030 ,China )
Abstract:Objective: To explore the Relationships Between Four TCM Syndromes And Cytokines/Hormones/BGP in Osteoporosis. Methods: Eighty cases were seperated into four groups according four TCM syndromes. The first TCM syndrome was spleen yan--deficiency,The second one was spleen and kidney yan--deficency,The third one was liver and kidney yin- defieeney,The fourth one was qi-blood stasis. Estradiol(E2)/ Testosterone(T)/IL-6/IGF-1/TNF-α /OPG and BGP were examined in the blood plasma In every case. Results: There was distinguishable difference between qi-blood stasis and kidney yan-deficiency in E2 (P= 0.008) ; There was distinguishable difference between qi-blood stasis and liver and kidney yin-deficiency in IGF-1(P= 0. 035), There was no distinguishable difference between other groups in T/IL--6/ TNF/OPG and BGP. Conclusion: E2/IGF- 1 can be treated as one of indexs of differentiation diagnosis between excess and deficiency, There are objective basis in differentiation of TCM syndrome.
Keywords:Osteoporosis  Cytokine  Hormone  BGP  TCM syndrome
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