补骨合剂对种植体-骨结合界面BMP含量变化的影响

目的：通过观察补骨合剂对口腔骨内种植体－－骨结合界面骨形态发生蛋白含量的影响，初步探讨补骨合剂促进骨整合的作用机理，为补骨合剂促进口腔种植体骨整合提供客观的理论实验依据。方法：成年杂种狗20只，拔除左侧下颌第2、3、4前磨牙，3个月后各植入钝钛种植体3枚。随机分为实验组和对照组，实验组予被骨合剂灌胃，分别于术后1、2、4、8、12周取出标本进行种植体－－骨界面骨整合情况观察。结果：实验组第1周种植体－骨界面骨形态发生蛋白（BMP）平均灰度显著增高（P＜0.01），较对照组提前约1周。结论：补骨合剂可以促进口腔骨内种植体骨整合。其可能机理：促进BMP的早期释放聚集，提高种植体－－骨界面的BMP浓度。

The Histomorphologic Study of the Effect of Bugu Capsule on the Osseointegration of Dental Implants

Objective:To investigate the mechanism of the effect of Bugu Capsule(BGC) on osseointegration and provide data for the practical use of BGC, by measuring related index of the influence of BGC on the dental implant osseointegration.Methods:A randomized, controlled experiment was conducted.20 adult dogs were divided two groups: experimented group and controlled group. Three left maxillofacial tooth were pulled out of all dogs, and were implanted with three titanium plast. The dogs of experimental group were ingested with BGC. The implanted maxillofacial part were sampled to observe the changes of implant-bone interface immedately 1,2,4,8,12 week after the surgery.Results:The level of BMP of experimental group is statistically significantly higher than that of controlled group the first week after surgery.Conclusion:BGC can promote the osseointegration of oral maxillofacial implants;The mechanism is to induce the release and congregation of BMP and increase the concentration increase the number an.